| Purpose:Observation of Gubenhuoxuepingchuanfang for elderly patients with COPD stable pulmonary function, peripheral serum hyaluronic acid (HA), type â…¢ procollagen (PCâ…¢) changes, to explore the side on airway remodeling and its possible mechanism.Method:In60COPD patients were randomly divided into treatment group and control group with30cases in each group. The control group received routine to salbutamol aerosol spray,12each time,3times a day; Ipratropium bromide aerosol spray,2each time,3times a day; Take Ambroxol30mg,3times a day; The use of nasal catheter oxygen, oxygen flow for1.02. OL/min, oxygen time10-15h/d. The treatment group in the control group received routine treatment based on Western medicine plus Gubenhuoxuepingchuanfang in treating. Daily1agent,2times a day. Two courses were observed treatment (15days for a course). Observel5days,30days after the clinical signs and symptoms scores, lung function, peripheral serum hyaluronic acid (HA), type â…¢ collagen (PCâ…¢) content and body mass index (BMI) change.The research results:1. Clinical signs and symptoms scores and body mass index (BMI) changes:Treatment for30days, in two groups of patients with clinical signs and symptoms scores declined, Compared with before treatment, With statistical difference (P<0.05), Between the two groups compared, also has statistical significance (P<0.05). The treatment group treatment for15days,30days of body mass index (BMI) is inclined, but no statistical difference.2.Improvement of pulmonary function:Treatment for30days, the two groups of patients with inspiratory capacity (IC), forced expiratory volume in the first second/forced vital capacity (FEV1/FVC) levels compared with before treatment inclinedly, With statistical difference (P<0.05), While the treatment group compared with the control group, there was significant difference (P<0.01).3.Peripheral blood HA, PCâ…¢ content change:Treatment for30days, in two groups of patients with HA, PCâ…¢ content compared with before treatment, There was significant difference (P<0.05). The treatment group and the control group for30days, HA, PCâ…¢ compared, but also has the difference (P<0.05).4.Correlation analysis:Pearson correlation analysis showed that collagen â…¢(PC â…¢) and HA, clinical signs and symptoms scores were positively related to (r=0.345,0.316, p<0.05) While the PC â…¢ and pulmonary ventilation function indexes of IC, FEV1/FVC were negatively related (r=-0.342,-0.336, P<0.05).Conclusion:Gubenhuoxuepingchuanfang can improve the stability of senile COPD patients with clinical symptoms, delaying their lung function deterioration, decrease of the content of Peripheral serum HA and PCâ…¢, may be one of the mechanisms of airway remodeling intervention. |
