Clinical Observation On Zhi Wu He Fang In Treating Perimenopausal Syndrome Of Deficiency Of Yin Of Liver And Kidney

1. Objective:Watch zhi wu he fang the treatment of liver and kidney Yin deficiency of perimenopausal syndrome of the clinical curative effect, and discuss the mechanism, to know the cl inical application of zhi wu he fang provide the scientific basis.2.Methods:Collected from July2010to July2011in hubei province jingzhou TCM hospital maternity clinics and the inpatient department meet the criteria60cases of perimenopausal syndrome patients, according to random CRT,60patients with patients were divided into two groups:treatment group35examples,25cases of control group. The treatment group and oral know five square, the control group Hormone replacement therapy (oral estrogen times with beautiful, treatment,0.625mg/day, even served28days,10days after the add take Ann palace of progestin,4mg/day), January for one period of treatment, for two consecutive period of treatment, observe the two groups of comparison and analysis of the clinical curative effect before and after treatment and improved Kupperman symptom scores (Kupperman index, KMI) change, testing two groups of serum estrogen2(estrogen2, E2), follicle-stimulating Hormone (Follicle-Stimulating Hormone, FSH), corpus luteum erythropoietin (luteinizing Hormone, LH) concentration level, monitoring of two treatments routine blood, kidney and liver function and gynecology, breast ultrasound, the effects of the observed treatment over3months after two groups of patients relapse3. Results:3.lEfficacy analysis: The total effective rate was86%in treatment group and control group in the total effective rate was84%, two groups of comparisons is no statistical difference (P>0.05).3.2KMI Zhi wu he fang KMI before treatment treatment group was28.73+/-10.61, after treatment for16.55±6.64, and was significant difference(P<0.01); Hormone replacement therapy KMI before treatment for the control group29.04±11.45,23.28±8.45after treatment, before and after was significant difference (P<0.01); And hormone replacement therapy compared with controls, zhi wu he fang KMI treatment group was significantly lower, significant difference (P<0.01).3.3Single symptoms score Compared with before treatment, the five after treatment with party know the feeling is unusual, damp sweat, insomnia, and emotional, depression, dizziness, headaches, heart palpitations, fatigue, waist sour backache, skin ant line feel ing, sexual pain dry, urinary infection vaginal single symptoms score significantly lower, and hormone replacement therapy only part of the control group single symptoms score lower, and zhi wu he fang treatment group in the lower sweat out feeling is unusual, hot flashes, insomnia, depression, dizziness, palpitations, tired single symptoms scored significantly better than hormone replacement therapy in control group (P<0.05or P<0.01).3.4Laboratory parameters Compared with before treatment, zhi wu he fang treatment group, five hormone replacement therapy after treatment level of serum E2control group were significantly increased, FSH and LH levels were significantly lower, statistically significant (P<0.01); After treatment, the two groups of patients E2, FSH and LH level is, no statistical difference (P>0.05).3.5Safety and adverse reaction Zhi wu he fang treatment group known for routine blood, urine and liver, kidney function, electrocardiogram, gynecology B to exceed, breast B super no influence on all, but hormone replacement therapy group compared with1cases of liver function abnormal.3.6Recurrence months after the end of therapy in patients with follow-up, knows the five＄party treatment group the recurrence rate was8.57%, much lower than the hormone replacement therapy group the recurrence rate was20%, statistically significant (P<0.05).4. Conclusion:4.1Know five side treatment with perimenopausal syndrome the cl inical curative effect of the exact, and western medicine hormone replacement therapy no difference4.2Zhi wu he fang can significantly increased the menopausal transition syndrome patients E2level, reduce the FSH and LH level, delay perimenopausal women ovarian function recession4.3Zhi wu he fang can significantly reduce the menopausal transition syndrome KMI patients4.4Zhi wu he fang, no adverse reaction4.5Zhi wu he fang after treatment with party know less recurrence...