Drug Intermediates5-Chloro-2-Pentanone And Analysis Of The Synthetic Testosterone

Drug intermediates5-Chloro-2-e ketones, English name for5-Chloro-2-pentanone, its alias has3-b-l-chlorine propane,1-chlorine e ketone-4, chloroquine phosphate is intermediate5-2b amino-2-e DuoZhong drug synthesis of ketone, starting materials, and has important application value. But the research and development production to situation, the industry is to belong to capital intensive, due to the limitation of the production process, easy to form production intermittent, investment intensity is bigger, in recent years, the United States and other developed countries some of the large pharmaceutical companies will this production line construction to developing countries, the use of labor advantage to reduce the production cost. The industry’s this characteristic mainly displays in its product price fluctuation has quite cyclical. Cause the situation of basic reason is that the5-chloro-2-e ketone production technology is not mature, the drug lab synthesis of raw material experiment still need to improve.Synthesis is at5-chloro-2-e of ketone literature to see, the synthesis of the compound technology literature does not see more, and the existing literature synthesized strict, synthetic lower yield, applied to practical production there are kinds of difficult to overcome the difficulties.This paper is mainly summarized in learning a lot about the organic synthesis of the literature material, and analyzes the advantages and disadvantages of various synthesis literature, the paper discusses the five-chloro-2-e ketone laboratory synthesis method, with the practicality for the research and development process purpose, safe, environmental protection, no pollution process design program, in order to can be used in the actual industrial production. First the molecular structured and space compound structure analysis, in order to considering previous synthesis of relevant literature, and the formula of synthetic52-e ketone of starting materials, in laboratory on the synthesis of the reaction conditions were discussed, has got the best reaction conditions.Finally, to laboratory production conditions for actual industrial application feasibility analysis and industrial production conditions of the discussion, and a few times pilot experiment and a production practice, which verify the production process in the industrial production of feasibility, with practical application value.