| Objective:To observe the clinical effect of treating idiopathic membranous nephr-opathy(IMN) with the methods of tonifying qi invigorate the circulation of blood,dredgecollaterals and dissipation agglomerate,and disscuss the next cure of IMN from kidneycollateral and abdominal mass, looking for one prescription suitable for most people.Methods:Fifty-six cases of biopsy-proven IMN were enrolled in this trial,withproteinuria＞3.5g/d.They were divided in two groups in chronological：experimentalgroup and control group.The control group were treated with tripterygium wilfordi whilethe experimental group were treated with tripterygium wilfordi and Yi-qi-tong-luodecoction. They would have a compare between the two groups for3months,6monthsafter the effect of the indicators.Results:Forty-nine patients completed6months observation,including25cases ofcontrol group and24cases of experimental group.(1)Compare by two groups ofoneselves:After3and6months,24hour urinary protein quantity and total cholesterol andtriglyceride decreased and albumin increased in the two groups(P＜0.05).The curativeeffect after six months were better than the three months(P＞0.05),and there was nodifference in creatinine(P＞0.05).(2) Compare between the two groups: After3and6months,experimental group was significantly better than the control group exceptcreatinine which was no significantly difference（.3）The total effective rate comparison:thecontrol group was64%while experimental group was75%after3months; the controlgroup was72%while experimental group was87.5%after6months.Experimental groupwas significantly better than the control group(P＜0.05). Conclusion:Yi-qi-tong-luo decoction could decrease24hour urinary proteinquantity,total cholesterol,triglyceride and increase albumin.It was safe and effective andworthy of clinical use. |
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