Chemically Modified Glassy Carbon Electrode For Sensing Paracetamol

Chemically modified electrodes (CMEs) are very active research area in electrochemistry and analytical chemistry. CMEs have been employed as drug sensor widely due to their high stability, selectivity and wide linear range, etc., recently lots of work has been reported already.Paracetamol (PCT) has been widely used as an analgesic and antipyretic drug around the world. The toxic side effect doesn’t happen when it was applied to those patients with aspirin-sensitive people in a certain dose, but the damage of the liver will occur when using too much or long-term. Therefore, it is necessary to develop a simple, rapid and accurate method to trace PCT.In this thesis, the relationship between the properties of CMEs sensing PCT and system temperature was carefully investigated. There three types of CMEs were prepared by the electrochemical method, they are4-aminobenzoic acid (4-ABA) covalently modified glassy carbon electrode (GCE,4-ABA/GCE), Pt nanoparticles (NPs) electrodeposited on GCE (PtNPs/GCE) and3-thiophenemalonic acid (3-TMA) electropolymerized on GCE (poly(3-TMA)/GCE). The modified GCEs were used to sense PCT at different temperatures, compared to the bare GCE. The results showed that the concentration of PCT is linear with the oxidation peak current. But the sensitivities of the electrodes namely the slopes of the linear regression equation are different at different temperatures. Those can be explained according to temperature effect on resistance of the electrodes and activity of PCT.