The Lipid Accumulation Product Is Better Than Waist Circumference To Identify Insulin Resistance In Women With Polysystic Ovary Syndrome

Aims To compare association of lipid accumulation product (LAP)and waist circumference (WC) with insulin resistance (IR) in women withpolycystic ovary syndrome.Methods121PCOS patients and115age-matched controls wereenrolled. Anthropometric index（including hight, body mass, WC） andfasting serum metabolic parameters(including lipid profile, plasma glucose,totol testosterone and high sensitive C reactive protein levels et al) weredetermined. An oral glucose tolerance test with75g glucose was performedon all subjects.90PCOS subjects and20controls underwenteuglycaemic–hyperinsulinaemic clamp to assess their insulin sensitivity,which was expressed as M value. The HOMA2-IR and LAP[(WC-58)*TG]were then calculated.Results Compared with control subjects, PCOS women hadsignificantly higher LAP and WC levels and decreased insulin sensitivity (P<0.05), Subgroup analysis showed that compared with age-andWC-matched controls, PCOS women still had decreased insulin sensitivityand increased LAP levels (P<0.05); Both LAP and WC are correlated withM value (r=-0.68, r=-0.66, P<0.01) and HOMA2-IR (r=0.55, r=0.49,P<0.01), and after adjusted for WC LAP still correlated with Mvalue(r=-0.37, P<0.01) and HOMA2-IR (r=0.26, P<0.01). Stepwise logisticregression analysis revealed that only LAP rather than WC could enter themodel as a significant variable in IR assessment. Binary logistic regressionanalysis revealed that the risk of IR in high LAP group was6.05times ofthat in the normal LAP group [Odds Ratio (95%CI):6.05(1.67,21.90),P<0.05].Conclusion In women with PCOS, LAP is associated with insulinsensitivity and it has a better correlation with IR than WC.