Response Of Children’s Lung Fuction To Nebulized Magnesium Sulfate

ObjectiveTo observe response of the children’s lung function to nebulizedmagnesium sulfate after acetylcholine provocation test, which is bettercompared to nebulized albuterol alone and whether a combination ofnebulized magnesium sulfate and albuterol is best.MethodsEighty four children with asthma in follow-up visit were recruited fromNovember2011to March2012and then randomly divided into three groups:magnesium sulfate group, albuterol group, group of combination ofmagnesium sulfate and albuterol. Patients in all three groups were nebulizedinhalaltion with acetylcholine as provocation test, then magnesium sulfate,albuterol, or combination therapy respectively. Lung function (FEV1, PEF)were compared between each group.ResultsLung function is improved after bronchodilation test in each group andthe value of FEV1and PEF is no significant different between eachgroup,but the increased rate of FEV1and PEF at10min after bronchodilation test is significant different in magnesium sulfate group orbetween albuterol group and combination group (P<0.05). In comparison oflung functions at different time points in all three groups, there is significantdifferent between the lung functions after bronchodilation test and afterbronchial provocation test in magnesium sulfate group and albuterol group（P<0.05）, combination group is opposite.ConclusionNebulized magnesium sulfate alone effectively improve lung function,but it is not better than nebulized albuterol alone at10min afterbronchodilation test,and the mechanism of synergistic effect is not clear.