Clinical Study Of Serum Ferritin In Maintenance Hemodialysis Patients

Objective:Through detecting levels of red cell count (RBC),hemoglobin(Hb), hematocrit (Hct), serum iron(S-iron), serum ferritin(SF), total iron binding capacity(TIBC), high sensitivity C reactive protein(Hs-CRP), albumin(Alb), calcium, phosphorus in MHD patients of Dali People’s Hospital, and comparing the correlation index of two groups of serum ferritin,anemia, micro-inflammation, nutrition, calcium and phosphorus metabolism, analyze the relationship of serum ferritin with anemia, micro-inflammation effect, calcium and phosphorus metabolism. in order to let local clinicians diagnose and treat MHD’S Complications reasonably.Methods:Sixty-seven maintenance hemodialysis patients were studied. Fasting venous blood samples were collected before dialysis.Monthly, measuring the levels of red blood cell count(RBC), hemoglobin(Hb), hematocrit(Hct), high-sensitivity C-reactive protein(Hs-CRP), albumin(Alb), calcium and phosphorus. And measuringthe levels of serum iron(S-iron), serum ferritin(SF), total iron binding capacity(TIBC) Once every three months. According to serum ferritin levels into the high serum ferritin group (serum ferritin>200ug/L) the low serum ferritin group (serum ferritin<200ug/L). Results and analysis conducted by the statistical software SPSS11.5. The relationships between serum ferritin and anemia, nutrition, micro-inflammatory markers, calcium and phosphorus metabolism were observed.Results:High serum ferritin group:Hb mean:94.18±16.89g/L, ALB mean:37.4± 5.27g/L, HS-CRP mean:27.9±15.2mg/L, P mean:2.36±0.64mmol/L, Low serum ferritin group:Hb mean:103.2±19.43g/L, ALB mean:39.74±3.15g/L, HS-CRP mean:19±6.22mg/L, P mean:1.89±0.65mmol/L. Comparing the two groups indicators was significant statistically (P<0.05).Linear correlation analysis:SF with RBC, HCT, HB and ALB was negatively correlated, the correlation coefficient r were-0.343(P=0.004),-0.304(P=0.013),-0.314(P=0.010),r=-0.275(P=0.024),and Hs-CRP, phosphorus levels positive correlation coefficients were:0.396(P=0.001),0.243(P=0.048). SF with serum iron, TIBC and calcium was no significant correlation (P>0.05). Between the two groups of gender, age, duration of dialysis, SCR, serum iron and TIBC was no significant difference.Conclusions:Serum ferritin levels commonly elevated in MHD patients of Dali autonomous Prefecture People’s Hospital. Serum ferritin levels reflect anemia, nutritional status, micro-inflammation, calcium and phosphorus metabolism changes. Elevated ferritin levels consistent with the severity of anemia. Show that: the use of iron barriers, insufficient EPO, EPO resistance, inflammatory state, may be involved in the process of increasing anemia, and not due to iron deficiency. Serum ferritin can be used as an indicator to evaluate the MHD patients with malnutrition, micro-inflammatory state, calcium and phosphorus metabolism disorders.