Discussion On Relationship Between Syndromes Of Deficiency And Excess With TCM And Body Specific Cell Immune In Chronic Hepatitis B Patients

Purpose:Nowadays, HBV infection is becoming a world epidemic trend as a serious threat to human health.Healthy energy and evils in conflict with each other is the theoretical marrow which TCM explains the process of disease generation and development.There was a close relation between immune function and healthy energy, however, few studies were done on between asthenia-sthenia zheng differentiation and the specific cellular immunity functions of HBV. The immune function of the specific cytotoxic T lymphocytes (CTL) and T lymphocyte according to asthenia-sthenia zheng differentiation are detdcted and analysed in our experiment to find out some objective evidences for more effective treating chronic hepatitis B patient for asthenia-sthenia zheng differentiation.Methods:90patients with chronic hepatitis B were enrolled into two groups according to asthenia-sthenia zheng differentiation, and control group is normal physical examinees. The specific cytotoxic T lymphocytes(CTL) and T lymphocyte subsets are detected by MHC pentamers in chronic hepatitis B patients. These dates are analysed by use of SPSS15.0statistical software for statistical analysis to investigate the relationship between asthenia-sthenia zheng differentiation and the specific cellular immunity functions of patients with chronic hepatitis B.Results:The levels of CD3+andCD4+in sthenia syndrome group and asthenia syndrome group are lower than control group, which in asthenia syndrome group are significantly lower than those in in sthenia syndrome group.The values of CD4+/CD8+in control group、syndrome group and asthenia syndrome is respectively following1.59±0.62,1.43±0.56,and0.83±0.16. The levels of CD8+in asthenia syndrome group are significantly lower than those in control group and sthenia syndrome group.The positive rate of specific CTL cell in sthenia syndrome group is higher than asthenia syndrome group significantly.Conclusions:(l)The positive rate of specific CTL cell in sthenia syndrome group is higher than asthenia syndrome group significantly.(2)The detectionThe positive rate of specific CTL cell and T lymphocyte subsets contributes to the objective standardied dialectical typing between syndromes of deficiency and excess.