| Erneture as one of the clinical common in jurys. have seriocsly affected the quality of life of the patients, how to promote the healing has always been the hot spot of the study, at present about how to promote the healing of the research has a lot of kinds, including all kinds of physical. chemical and biological met hods. Research has shown that constant strong rotating magnetie field can promote bone call proliferation and lifferentiation, for osteoporosis have certain treatment effert, but the applieation of constant strong rotating magnetic field in the research of fractore healing has few reports in the literature. This studs aims to throush the use of constant strong retating magnetic field in the Eracture healing of rats to study its iuteryention in the role of the Eracture healing.We select elshty2months.3months of male SD rats only. use closer Eracture model for the research, with random access method to (?) the SD rats into the natural healing group Groue W and magnctic field interention group (M group). M rats will be set in0.4T constant strong rotating milenetic field in30minules/day intervention treatment. six times a week. Through comparing the different erouns of SD rats to judge constant strotig rotating magnetic field in the role of the fracture realing, and use the (?) method to compare the changes of VEGF. aFGF. bEGF. IGF β1and tGF-β2to explore the mechanism of constant strong rotating magnetic field in fracture healing.The resulrs found that the VEGE OD value of M2is higher than that in The C2group (P<0.01). the OD value of M3, M4also siznifieaut (P<0.01); than that in natural group (P<0.05);2weaks and4wecks M group bFGF OD values compared with the C group have signifieant difference (P<0.01); M2TGF-β1OD value signifieantly higher than that in C group (P<0.05), the TGF-β2OD value of M4yrogp signilicantly higher than that in C group (P<0.01). and the rest of the group has no difference.The study concluded that compared with the natural healing, constant strong rotating magnetic field can obviously promote the intervention callus growth Constatant strong intervention can promote VEGF rotating magnetic field induced the formation of blood vessels ability increases, constant strong roptating magnetic field in two weeks and three weeks in significantly promote bFGF expression, in the four weeks of promoting the expression of aFGF, Constant strong rotating magnetic field in the two weeks after the fracture promote TGF-β1expression, and may promote mesenchymal cells for the proliferation and differentiation of cartilage cells and the osteoblast and participate in the fracture of the relevant repair; And after3and4weeks of the fracture can significantly promote TGF-beta2expression, indicating that the magnetic field not only make intervention TGF-beta2continuous transformation of cartilage cells ability strengthens, may also has some relationship with the osteoblast activity. |
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