Study On Prevalence And Risk Factors Of Mild Cognitive Dysfunction In Tianjin Elderly Community

Objectives1.To investigate the prevalence and distribution of MCI and related socio-demographic factors among aged population in Tianjin society.2.To identify the injury characteristics of MCI and its risk factors including the effect of amyloid precursor protein gene.MethodsThe multi-stage random cluster sampling method was used among aged population (≥60years) in Nankai District, Tianjin for prevalence survey. Six communities including Yuanyinli community, Yingshui street community, Yingjiangli community, Huayuan community, Jinhuanli community, Xinxiali community were selected.1:1-matched case control study was carried out. The case group patients are all the patients who were diagnosed as mild cognitive dysfunction (MCI) in above prevalence study. The control group was the people who were diagnosed as without MCI. They are1:1matched with cases respectively by gender and age (±3years). Participants were all live in Tianjin for more than five years. They are willing to cooperate with this research, accept the questionnaire survey, cognitive function test and the corresponding laboratory, and provid complete objective information. SPSS16.0statistical package was used to analyse the data. Univariate and multiple variate analysis were conducted by conditional logistic regression to explore the risk factors of MCI. The mini-mental state examination (MMSE) and Wechsler adult intelligence scale-revised of China (WAIS-RC) were used to screen patients of mild cognitive impairment.Results1. There were3762subjects meeting the inclusion criteria, and we investigated3678in all. Of367860years old and above subjects,408met the MCI standard, the prevalence was11.1%. The scores of MMSE were19.88+3.65and28.01±1.85(x±SD) in MCI and control groups respectively. In comparison to the scores between two groups with t test, the results showed there is a significant difference (t=-44.235, P=0.000). The prevalence of MCI was lower in male than in femalc(χ2=15.622, P=0.000). The prevalence of MCI was associated increased with age and decreased as monthly income increased.2.132pairs of case and control were selected as study subject. The average scores of case group were lower than in control group including Knowledge, Arithmetic, Digit Span, Picture Completion, Block Design, Picture Arrangement, Episodic Memory, Spatial Reasoning, Listening and Verbal Memory(P<0.01). High systolic blood pressure(P=0.036, OR=13.740,95%CI:1.184～159.413)、high APP optical ratio (P=0.004, OR=15.184,95%CI:2.440～94.496) were the risk factors of MCI for community elderly, and mental laboring was the protective factor (P=0.038, OR=0.231,95%CI:0.058～0.920).Conclusions1. This study confirms the high prevalence of MCI among60years old and above population in community. Cross-sectional study shows that female, low monthly income maybe the risk factors of MCI.2. The attention ability, memory ability of MCI patients decrease significantly in comparison to people without MCI. High APP optical density and high systolic blood pressure are the risk factors and mental work is a protective factor for60years old and above in community.