The Effect Of Polyenephosphatidylcholine On Prevention And Treatment In Rabbit Atherosclerosis Model

Objective: To observe the effect of polyenephosphatidylcholine (PPC) inatherosclerosis lesions, the therapeutic and preventive effect of them at the level ofinflammation with non-alcoholic fatty liver disease (NAFLD), injury in vivo heart, liverand kindey vital organs change, the possible mechanism of polyenephosphatidylcholinein preliminary discussion. Methods:51male New Zealand rabbits were divided into fourgroups, model group (n=14), polyenephosphatidylcholine group (n=13),polyenephosphatidylcholine plus aspirin group (n=12), pravastatin plus aspirin group(n=12). Experimental time of12weeks, weighing1weight per week. Ultrasounddetection of the first2weeks,5weeks,8weeks and12weeks of the common carotidartery and abdominal aorta IMT. Pathological observation of the common carotid artery,aorta, liver, heart and kidney pathology. Serum biochemistry, blood lipids, creatinine anduric acid levels. Serum8-OHdG, TRX,4-HNE,8-iso-PGF2α, LEP, ADPN, FFA, ET, IL-6,TNF-α, MDA, MCP-1, hs-CRP, NOS, NO, GSH, reduced glutathione, GSH-Px levelswas detected by ELISA. Results: The carotid and abdominal aortic intima IMT in fourgroups was not statistically significant. Weight between the groups was not statisticallysignificant. Each group aortic lipid deposition in plaque size under intima wasstatistically significant (P<0.05), aortic wall thickness, medial thicknessthe and thicknessof lipid deposition in each group was not statistically significant (P>0.05). Theballoon-like degeneration of liver fatty degeneration of liver was not statisticallysignificant (P<0.05). Pathological cardiac lipid deposition was not statisticallysignificant(P>0.05), kidney pathological lipid degeneration of tubular epithelial cellswere statistically significant (P<0.05). The serum level of TC was statistically significant(P<0.05), while the other serum biochemical parameters were not statistically different (P>0.05). Oxidative stress, lipid peroxidation, inflammation and other18related to thelevel of serum cytokines among groups were not statistically significant (P>0.05).Conclusion: Rabbit NAFLD and atherosclerosis model are successfully reproduced.Polyenephosphatidylcholine could alleviate inflammation in nonalcoholic fatty liverdisease and decrease the percentage of lipid deposition in intimal area of the aortic arch,it display protect the liver and has a blocking role in the atherosclerosis, the mechanismof action of polyenephosphatidylcholine is worth further exploration.