Different Type Certificate In Patients With Asthma Who Body Fluids, And Peripheral Blood Related Researches On The Change Of Immune Index

Objective: According to the different type certificate in patients with asthma whosaliva, sputum, nasal secretions secretory in immunoglobulin A （SIgA） and blood CD₄⁺,CD₈⁺T lymphocytes, eosinophilic acidic cationic protein （ECP）, serum total IgE （T-IgE）discussed were the attack of asthma mechanism, In order to further understand thedevelopment of childhood asthma mechanism, and also summarizes different card typeasthma the changing characteristics of the relevant immune index, for Chinese medicineto asthma on syndrome differentiation and classification provides an objective basis forprevention and cure of bronchial asthma and provide theoretical basis. Methods: Collectdifferent card type200patients with asthma （asthma group） and normal30cases （normalgroup）, using the method of ELISA sputum, saliva and nasal secretions SIgA of the weekoutside the venous and ECP, T-IgE testing; The flow cytometric the blood of CD₄⁺, CD₈⁺T lymphocytes were detected. Results:（1） asthma in the blood of CD₄⁺, CD₈⁺Tlymphocytes, CD₄⁺/CD₈⁺expression compared with normal group are increased, astatistically significant （P<0.05）; Different type certificate in patients with asthma who inperipheral blood CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺compared to no difference obvious （P>0.05）.（2）asthma group of saliva, sputum, nasal secretion of SIgA content are the normal groupreduced significantly, and was statistically significant （P<0.05）; Different type certificatein patients with asthma who SIgA content found in saliva compared to no significantdifference was statistically significant （P>0.05）; Different card type between patientswith asthma sputum SIgA content in comparison was statistically significant （P<0.05）,cold wheezing patients in the sputum SIgA content is higher than the wind wheezing,virtual wheezing sputum, cold bag hot wheezing patients （P<0.05）, and the rest betweeneach group there were no significant difference （P>0.05）;Every syndrome type between patients with asthma in rhinal secretion SIgA content is statistically significant compared（P<0.05）, cold wheezing patients in rhinal secretion SIgA content are lower than thewind, cold hot sputum wheezing bag wheezing patients （P<0.05）; The rest between eachgroup compared to no difference obvious （P>0.05）.（3） every syndrome patients withtype serum T-IgE、ECP content is not statistically significant （P>0.05）. Conclusion:（1）The bronchus asthma patients with acute episode exist in immune function disorder;（2）Asthma patients in acute episode in the peripheral blood immune index CD₄⁺, CD₈⁺Tlymphocytes, T-IgE and phlegm, saliva, nasal secretion of SIgA happensdisorder,inclding the upper respiratory tract secretion of immune index SIgA changeparticularly obvious;（3） According to Chinese medicine diagnosis and classification, coldwheezing type of immune index in patients with asthma who most obvious change. So inasthma in the prevention and control of the immune function of patients with asthmacorrect balance disorders especially important, to the upper respiratory tract secretion ofimmune index test related will help understand the serious attack of asthma in traditionalChinese medicine and in traditional Chinese medicine for asthma syndrome type provideobjective theoretical basis points.