Correlation Between Insulin Resistance And Myocardial Injury In Critically Ill Children

Objective: To study the relationship between insulin resistance and myocardial injuryin children with critical diseases in light of the fact that such children usually suffer fromnoticeable insulin resistance and myocardial injury. Methods: Sixty-three children withcritical diseases who were admitted between march2010and june2011were enrolled tocomprise a case grop. Fasting blood glucose, serum insulin, cardiac enzyme, and troponinI (CTnI)levels were measured. The insulin resistance index (HOMA-IR) was calculated.The children were classified into two groups: insulin resistance (HOMA-IR＞1.0, n=30)and non-insulin resistance (HOMA-IR≤1.0, n=33). Thirty healthy children served as thecontrol group. Results: HOMA-IR, lactated Lactate dehydrogenase (LDH), Nmdaamino shift enzyme (AST), Creatine kinase (CK), Creatine kinase isozyme (CK-MB),α-butyric acid dehydrogenase (α-HBDH) and CTnI were higher than those in thenon-insulin resistance and the control groups (all P＜0.05). The non-insulin resistancegroup also showed obviously higher levels in terms of LDH, CK, CK-MB, AST, α-HBDHand CTnI than the control group (P＜0.05). In the insulin resistance group, there exists apositive correlation between HOMA-IR and such indicators as LDH, CK, CK-MB, AST,α-HBDH and CTnI (r=0.697,0.739,0.781,0.792,0.642,0.381, respectively; all P＜0.05).Conclusion: Insulin resistance makes myocardial injury more serious; HOMA-IR canserve as a forecast indicator for the degree of myocardial injury.