The Mutations Of Epidermal Growth Factor Receptor Gene And The Clinnicopathological Features In Uygur And Han Lung Cancer Patients

Objective:To analysis the relationship between the mutations of epidermal growthfactor receptor gene and clinicopathological features in lung cancer of Uygur and Hanpatients.Methods:Scorpions amplification refractory mutation system(Scorpions ARMS)was used to detect the mutations of EGFR gene(exons18,19,20and21) in100cases oflung cancer tissues.Tumor cells were collected by microdissection from paraffinembeddedtumor specimens obtained respectively from50Uygur and Han patients.Results:The EGFR mutation rate in Han patients was significantly higher than that of Uygurpatients,30%(15/50) vs.12%(6/50),P<0.05. EGFR mutations were detected in15of50(30%) Han patients with NSCLC.There were11cases of the mutations in exon19and4cases of the mutations in exon21.The EGFR mutation rate in females was significantlyhigher than that of males,47.4%（9/19）vs.19.4%（6/31）,P＜0.036.The mutation rate ofEGFR gene of non-smokers was higher than that of smokers,45.5%（10/22）vs.17.9%（5/28）,P=0.035.The mutation rate in patients with adenocarcinoma was higher than thatin patients with other cancer types,40.6%（13/32）vs.11.1%（2/18），P=0.029。EGFRmutations were detected in6of50(12%) Uygur patients.There were4cases of themutations in exon19and2cases of the muations in exon21.Compared adenocarcinomawith non-adenocarcinoma,EGFR mutation rate was statistically significant(P<0.05) andthe former had higher mutation rate.Also,the relationship between EGFR mutations andvarious clinicopathological factors suggested that there is no significant difference.Therewas no association among gender, age, smoking,TNM stages, lymph nodemetastasis,(P>0.05). Conclusions: EGFR gene mutations occur more frequently infemales, non-smkers and patients with adenocarcinoma of Han patients, and morefrequently in adenocarcinoma subtype of Uygur patients. The detection rate of EGFRmutation is remarkably lower in Uygur patients than Han patients.