Clinical Analysis Of Maximal Androgen Blockade And Intermittent Hormonal Therapy In The Treatment Of Advanced Prostate Caner

Objective: To investigate the comparison of maximum androgen blockade therapyand intermittent hormonal therapy in advanced prostate cancer treatment efficacy, sideeffects, treatment costs, etc. Methods:29patients with prostate cancer were divided into2groups,13patients received maximum androgen blockade treatment and16patientsreceived intermittent hormonal therapy. The2groups were for12months of follow-upreview, records serum prostate specific antigen PSA level, serum testosterone levels, theaverage treatment time, side effects, during the course of one week after treatment,1month after treatment,3months after treatment,6months after treatment,9months aftertreatment,12months after treatment, and the comparison between the two groups.Results: During the course of one week after treatment,1month after treatment,3months after treatment,6months after treatment,9months after treatment,12monthsafter treatment, review the serum PSA value respectively, there are no difference betweentwo groups. After9months of treatment, and12months after treatment of serumtestosterone values, the two groups have differences. IHT group average treatment time isless than the MAB group. IHT group progress percentage of the number of cases is lessthan the MAB group. IHT group with hot flashes and breast pain symptoms of patients isless than MAB group. Conclusion: Intermittent hormonal treatment and maximumandrogen blockade are both applicable to androgen-dependent prostate cancer, thetreatment effect of two groups is considerable. Intermittent hormonal therapy wassignificantly value in the patient with less side effects, lower cost and improvement of thequality of patients survival, therefore IHT should be the preferred treatment of advancedprostate cancer.