The Correlation Of Body Mass Index And Plasma Aldosterone Concentrations In Overweight-obese Primary Hypertensive Patients

Objective: Bodymass index (BMI) shows a direct correlation with plasmaaldosterone concentration(PAC) and urinary aldosterone excretion in normotensiveindividuals;whether the same applies to hyertensive patients is unknown. our objectivewas to determine if BMI predicts PAC and the PAC/plasma renin activity ratio[aldosterone renin ratio (ARR)] in hypertensive patients, and if this affects theidentification of primary aldosteronism (PA). Methods: selected190cases diagnosedEssential hypertension,178cases diagnosed primary aldosteronism,from January2008toApril2011at the Xinjiang Uygur Autonomous Region People’s Hosptial,Department ofhypertension. Main Outcome Measures: Body Height, Body Weight, The body mass index(BMI),contractive pressure, diastolic blood pressure, course of disease, serum creatinine,cholesterol total, low-density-lipoprotein, triglyceride,potassium,serum sodium, SittingPAC, plasma renin activity, and theARR, salt water test, According to body massindex,divided into normal weight,overweight and obesity group.The difference amonggroups was compared and the relationship of all indexes was analyzed. Results: BMIcorrelated with PAC in EH, but not in PA patients. This association of BMI is particularlyevident in overweight-obese EH patients. However, it does not impact on the diagnosticaccuracy of the ARR for discriminating PA from PH patients. Conclusions: BMIindependently predicted PAC in EH, particularly in the overweight-obese,but not in the PAgroup.