| Objective:This cl inical study is to observe MeiHuaZhen knock at spurs with Chinese medicine (Vaccaria segetalis powder) external treatment herpes zoster neuralgia (PHN) possibly clinical effectiveness and safety, by means of measuring the treatment group and control group before and after treatment in patients with pain intensity score (VAS grading), analgesic effect to time and sleep quality changes, observe the curative effect and safety, for herpes zoster neuralgia, possibly offer effective treatment methods.Research methods:Hospital dermatological outpatient service in hubei province in March2011to November2011herpes zoster neuralgia, possibly patients as the research object, the researchers used by professional Chinese medicine outpatient service of completing the way of all patients gender, age, affected nerve, precursor pain, first time to treatment, treatment, the acute phase of pain, damaged area, skin rash, type, complications, herpes recovery time clinical data of records and fill in the general information form.65cases of patients with random observation PHN,29cases of men and women in36cases, age43-82years old, pain, distributed mainly in the face ministry, shoulder, metal-studded neck, back and the place such as the lower limbs. Selected patients were randomly divided into two groups, namely MeiHuaZhen knock at spurs Vaccaria segetalis powder with Chinese medicine therapy group (n=33treatment group, and He-Ne laser irradiation lesions with local injected drug therapy to western medicine (control group, n=32), two groups of cases in age, sex, and the course, healing aspects such as before rating, difference have no significant meaning (P>0.05), comparable.A week before the observation of the discontinued all other PHN treatment. Treatment:treatment group with Vaccaria segetalis powder, egg qing, vaseline for raw materials do as the Vaccaria segetalis, pain in regular disinfection, Me iHuaZhen knock at spurs15minutes to reddish skin for degrees, will stick in the ointment pain skin area, the daily change medicine again. The control group to He-Ne laser irradiation after15minutes, with2%hydrochloric acid lidocaine, vitamin B1, vitamin B12to fit with new drug, pain skin area to do her lesions injected once a day. The treatment group and control group respectively according to the corresponding method to treat,5days for one period of treatment, after a period of treatment began to observe and record curative effect,3course stop treatment, stop after treatment, the two groups observe patients of the river pain conditions, and were followed up for6months, according to the analgesic effect, recovery rate, how many and follow-up treatment after half a year on the recurrence rate curative effect evaluation, through the observation of evaluating the results MeiHuaZhen knock at spurs Vaccaria segetalis powder with treatment for herpes zoster neuralgia, possibly the clinical curative effect.The analysis of the clinical data of the statistical software SPSS18.0analysis, count the X2test data, the grade material using Ridit analysis, measurement data using t test. P<0.05as a significant difference value world. Results:1. The PHN factorOf65patients showed clinical observation, PHN and effect of age of onset, her lesions area, course and related factors such as disease, shingles patients age of onset, the area is small, small lesions of short duration, illness light therapy effect is better, and curative effect is poorer. And PHN curative effect and the sex, affected nerve, no significant correlation.2. MeiHuaZhen knock at spurs Vaccaria segetalis powder with clinical observationAfter five treatment after treatment, the two groups of the statistics analysis, MeiHuaZhen knock at spurs Vaccaria segetalis powder with Chinese medicine therapy for PHN has a remarkable healing effect, can significantly ease pain patients, improve patients’sleep quality. The treatment group and control group before treatment pain without significant difference (P>0.05), for1treatment pain relief started time has significant difference (P<0.05), the treatment group than in control group, reducing pain degree between the two groups have significant difference (P<0.05); The treatment group clinical cure the number needed treatment is less than that of the control group (P<0.05); After six months follow-up results display treatment group and control group the long-term outcome have significant difference (P<0.05); Between the two groups before and after treatment and the total effective rate of recovery is all have significant difference (P>0.05).3. Safety, adverse reactions and inverse analysisTwo groups of all did not appear adverse drug reactions. According to stop treatment followed after the river pain, Chinese medicine therapy group that have rebounded in1case of pain, a rate of3.03%, western medicine therapy group have9cases of sexual pain appear bounce, was28.13%, and the difference between the two groups of comparisons statistical significance (P<0.05).Conclusion:Through the65cases of patients with clinical study looked at the PHN, found that MeiHuaZhen knock at spurs Vaccaria segetalis powder with total curative effect is better than western medicine therapy treatment, can significantly ease herpes zoster neuralgia, possibly, improve sleep quality, improve the quality of life. This method of low cost, simple operation and efficacy is obvious, safety and no side effects, PHN security for effective treatment, worth in clinical application. |
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