| Objective:Observed Qingrejiedu dispelling wind and dampness law (anti-drug mixture) the clinical efficacy of the treatment of foot and mouth disease, and to explore the safety of the anti-drug mixture, to provide new ideas for the clinical treatment of hand, foot and mouth disease, to change the current Western medicine treatment of hand, foot and mouth disease no specific method of prescription status quo, and to lay the foundation to provide effective and safe drug to reduce the incidence of severe hand, foot and mouth disease.Methods:Select the children with hand, foot and mouth disease diagnostic criteria61cases were randomly divided into treatment and control groups. Treatment group31cases, including17males and14females, aged5years old in June, the average age of1.826±.965years of age, duration of1-5days. Control group of30cases, including16males and14females, aged5years old in June, the average age of1.717±0.749years of age, duration of1-5days. Two groups of children with sex, age and duration of statistically significant differences comparable.Control group, treatment of HFMD diagnosis and treatment guidelines issued by the Ministry of Heal th in2010; treatment group on the basis of this anti-drug mixture orally or by retention enema (June-1years of age:10ml/times, three times a day;1-3years old:15ml/times, three times a day;3-6years:20ml/times, three times a day). The treatment lasted7days. Observed changes in symptoms, signs and laboratory parameters in the two groups of patients, and a comprehensive clinical evaluation. The statistical analysis using statistical software SPSS13.0, classification data using the x2test, measurement data using t test, ranked data Ridit analysis method.Results:1, two sets of the total efficacy of treatment groups were compared the cure rate is90.32%,96.77%of the total effective rate; cure rate was70%in the control group, the total effective rate was86.67%, the difference between the two groups were statistically significant (P<0.05), indicating that the treatment group than the control group.2, two sets of symptoms, the treatment group mean fever clearance time was2.731±1.069days, the average rash subsided3.778±1.609days, the mean fever clearance time of the control group was3.828±1.860days, the average rash subsided6.052±1.551days; difference between the two groups by comparison were significant (P<0.05), indicating that the cooling time of the treatment group and the rash subsided than the control group were significantly shorter; two groups a total of44cases of cough symptoms, the treatment group21cases, the average The recovery time was2.397±0.518in the control group (n=23), the average healing time was4.729±1.021days; a total of41cases of severe vomiting,20cases in treatment group, the average heal ing time was1.636±1.210days,21cases of the control group, the average2.532±1.228days; symptoms of dry stool, a total of56cases, the treatment group and29cases, the normal average time for recovery was3.008±1.209days, the control group (27cases), the average time of4.347±1.761days; two groups of coughing, vomiting The difference in statistics and stool dry and cure time on more meaningful (P value<0.05), indicating that the treatment group, dry stool, coughing, vomiting, recovery time is shorter than the control group.3, two groups of severe cases, the incidence of treatment group1patients developed severe cases, severe cases accounted for3.23%of the control group, four cases of the development of severe cases, accounted for13.33%of severe cases, two sets of statistical comparisons showed significance (P<0.05), indicating that the treatment group than the control group in reducing the severe cases occur.4, After treatment, serum EV71antibody clearance time by the treatment group, serum EV71antibody negative30cases, the average clearance time of4.398±0.751days, the control group was negative for25cases, the average clearance time was5.163±0.906days; two sets of statistical significant difference (P<0.01), indicating that the treatment group than the control group in the time of serum EV71antibody negative.Conclusion:Qingrejiedu dispelling wind and dampness France (antitoxic mixture) treatment of hand, foot and mouth disease, the total effective rate was96.77%, the total cure rate was90.32percent, more effective than conventional Western treatment group; the main symptoms, the mean fever clearance time was2.731±3.778±1.609days1.069days, the average rash subsided, can significantly shorten the hand, foot and mouth disease hot process and the rash subsided time; times disease cough average heal time of2.397±0.518in days, vomiting average heal time of1.636±1.210days, dry stool The average healing time was3.008±1.209days, reduce the secondary symptoms (stool dry and hard, coughing, vomiting) recovered significantly better than conventional Western treatment group on time; only one cases the development of severe cases, severe cases accounted for3.23percent, reducing cases of severe disease occurred superior to the conventional Western group; serum EV71antibody negative after treatment,30cases, the average clearance time of4.398±0.751days, shortening the time of serum EV71antibody negative than the control group. Through clinical research:anti-drug mixture to clearing and detoxifying, dispelling wind and dampness of the effectiveness of HFMD of fever and rash subsided significantly shorten the time, as soon as possible to improve the dry stool, coughing, vomiting and other symptoms, reduce the number of severe cases, shorten the serum EV71antibody clearance time is a clinically effective drug for the treatment of hand, foot and mouth disease, and did not find treatment-related toxicity; Qingrejiedu dispelling wind and dampness France is the main treatment for HFMD Dafa, it is worth further study. |
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