How Did Two Kinds Of Gastrointestinal Reconstruction Affect Cholecystokinin

Objective:In this study, we collected patients’serum who had gastric cancer preoperative and postoperative after a meal, did research of cholecystokinin(CCK) as the object, discussed CCK variation regular pattern of the gastrointestinal tract reconstruction patients with gastric cancer preoperativly and postoperativly, thus it could provide theoretical basis due to superiority of gastrointestinal tract reconstruction. According to this, prognosis of patients stomach cancer could be known best. Method:In this research, we collected40patients from2009to2010who were diagnosed with gastroscope gastric cancer (no matter what its’somatotype, stages, invasion and metastasis), and randomly divided into two groups. There were no significant different clinical parameters within two groups in age, gender, tumour stage and differentiation degree (P>0.05). Group A which was reconstruction way for food through the duodenum and jejunal contained25people (including Billroth I,Adjustive Double Tract Digestive Reconstruction of Total Gastrectomy etc); Group B which was reconstruction way for food not through the duodenum and jejunal contained15people (including Billroth II, Braun anastomosis, Roux-en-Y, Stomach jejunum anastomosis etc)。 One days before operation two Fried eggs were eaten and then after half an hour, Blood samples were collected into chilled tubes containing3.9μ mol of EDTA per mL of blood and30u L/5mL (150IU) aprotinin. Within30min, the samples were centrifuged at3000g at4℉℃for10min. The plasma was stored at-20℃until extraction。 After two weeks two fried eggs were also eaten in the same way, and mearsuring CCK concentration (enzyme-linked immunosorbent method). Statistical data was dealed with SPSS14.0by Independent-Samples T Test and Paired-Samples T Test. Measurement data resulted to x±s, P<0.05showed a statistically significe. Result:1Preoperativly the CCK concentration of group A after a meal was4.54+.50pmol/L, group B was4.46+0.51pmol/L, there was no significant differences (t=0.458, P=0.65,P>0.05).2Postoperatively the CCK concentration of group A after a meal was5.38+1.03pmol/L, compared with the preoperation,there was significant differences (t=-4.7, P<0.05).3Postoperatively the CCK concentration of group B after a meal was4.21+0.53pmol/L, compared with the preoperation,there was significant differences (t=3.18, P=0.007,P<0.05).4Compare the CCK concentration between group A and B,A was higher than B,there was significant differences(t=-4.07,P<0.05).Conclusion:1Plasma CCK was improved after patients undergoing radical gastrectomy and gastrointestinal reconstruction, keeping duodenal channel.2Plasma CCK was lower after patients undergoing radical gastrectomy and gastrointestinal reconstruction, not keeping duodenal channel.3 Compare reconstruction way of keeping duodenum channel compared with not keeping way, the former plasma CCK concentration was increased significantly.