Study On The Change Of The Concentration Of IL-17in Periphal Blood From Wheezing Infants Infected By Respiratory Syncytial Virus

Objectives:To detect the concentration of interleukin17(IL-17) in peripheral blood of wheezing infant patients, who were infected by respiratory syncytial virus (RSV) or not infected in acute and remission stage, and investigate the relationship between IL-17lever and RSV infection in wheezing infants.Methods:All these wheezing infants were recruited from the peadiatrics department of the Fourth hospital in Changsha from February15,2011to April30,2011, less than3years old and not treated with glucocorticoid yet. The wheezing infants who were caused by cardiac asthma, pulmonary tuberculosis, whooping cough, foreign body in bronchus,air obstruction and congenital malformation were excluded. All the wheezing infants were divited into two groups by whether infected by the RSV, RSV-infected group and non-RSV-infected group. Another20healthy infants acted as control goup. The age and gender in three groups were not significantly different. Serum samples from the wheezing infants and control cases were collected and tested the RSV-IgM and IL-17concentration by enzyme-linked immunosorbnent assay (ELISA). Rusults:1. The serum concentrations of IL-17in RSV group and non-RSV group in acute stage were respectively higher than that in normal control group(34.69±4.44vs21.02±2.78,31.05±3.59vs21.02±2.78, P <0.05).2.The serum concentration of IL-17in RSV group in acute stage was higher than that in non-RSV in acute stage(34.69±4.44vs31.05±3.59,P<0.05).3. The serum concentration of IL-17in RSV group in remission stage was lower than that in acute stage(21.03±3.70vs34.69±4.44, P <0.01). Also the serum concentration of IL-17in non-RSV group in remission stage was lower than that in acute stage(22.25±2.25vs31.05±3.59,P<0.01).4.The serum concentration of IL-17in RSV group and non-RSV group in remission stage and normal control group showed no significance difference (21.03±3.70vs22.25±2.25,21.03±3.70vs21.02±2.78,22.25±2.25vs21.02±2.78, P>0.05).ConclusionsThe concentration of IL-17in periphal blood from wheezing infant patients was higher than that in normal control group. And it was higher in RSV group than that in non-RSV group. After the symptom of wheezing relieved, the concentraion of IL-17was reduced significantly. Our study suggested that Thl7/IL-17played an important role in the occurence of wheezing in infants, and RSV infection might be one of important reason for cause the change of Th17/IL-17.