Effects Of The Xuebijing Injectionon Of Lung Function In Patients With Mods

Objective： To investigate the effect of Xuebijing Injection on inflammatorymediators、extravascular lung water and respiratory function in multiple organ dysfunctionsyndrome (MODS)。Methods：Forty-one adult patients were choosed form a variety of causes inQianfoshan hospital with MODS，randomly divided into control group(given to compreh-ensive treatment of conventional Western medicine，Including infection control, respir-atory support，to maintain hemodynamic stability，improve microcirculation，nutritionalsupport，and other organ support therapy)and treatment group(Based on the comprehensivetreatment of Conventional Western medicine given to Xuebijing injection100ml plus100ml0.9%saline intravenously，every bit of time in30-40minutes，2times a day，7days)。Placement PiCCO catheter，monitoring,extravascular lung water index (EVLWI)and intrathoracic blood volume index (ITBVI) changes。Record peak airway pressure(Ppeak)，lung compliance (Cdyn) and blood gas analysis。Results： After7days treatment， and monitoring of inflammatory mediatorsinterleukin-6(IL-6)，tumor necrosis factor (TNF-α) significantly reduced，EVLWIreduced, ITBVI stabilized。 Ppeak and Cdyn improved， oxygenation index wassignificantly improved。 Compared with control group differences were statisticallysignificant (p <0.05)。Conclusion：Xuebijing injection can reduce the inflammatory mediators, reduceMODS in patients with extravascular lung water and improve respiratory function, improve the success rate.