| Objective:Recurrent spontaneous abortion is common obstetrics and gynecology diseases, for patients and their families bring pain and burden. Modern medicine at present for unexplained recurrent spontaneous abortion treatment, there is no certainty treatment and exact curative effect, while the traditional Chinese medical science invigorate the method of nourishing kidney and promoting blood circulation in the treatment of the disease process has good curative effect and the development prospect. ZHU YUN NING No.1is Heilongjiang university of Chinese medicine hospital affiliated first court of the agreement a prescription, after years of clinical application, has achieved significant clinical effect. This topic for discussion ZHU YUN NING No.1on the treatment of recurrent miscarriage mechanism of action, and Th1/Th2balance, proposed by watching the party for clinical45cases of recurrent miscarriage kidney patients with type the curative effect of analysis, this paper discusses ZHU YUN NING No.1and Thl type of cells factors, Th2type of cell factors regulating mechanism, explore Th1/Th2balance and recurrent miscarriage TCM syndrome type of correlation, perfect the pharmacodynamics study, so as to further research to ZHU YUN NING No.1and Th1/Th2balance recurrent miscarriage of treatment to provide the theory basis.Methods:45patients who measure up to the standards, randomly divided into treatment group (ZHU YUN NING No.1with dydrogesterone group) and control group (dydrogesterone group) on two groups of the patient’s age, abortion, the process of analysis and observations on treatment in Chinese medicine for the improvement of the situation warrants, serum and the promotion of β-subunit chorionic gondaotropin and Progesterone changes. Observed before and after treatment of traditional Chinese medical syndrome improve human, serum of gonadotropins (β-HCG) level, progesterone (P) level, Uses ELISA examine the blood IL-10level and TNF-α level the con tent. Observed the calculation of Thl before and after treatment (TNF-α/Th2(IL-10) of the ratio of the change.Result:4patients lost.Treatment group21patients,heal11,9improved,1failed, the effective rate was95%;20patients of control group,heal5patients,10cases improved5patients failed, and the effective rate was75%.41patients with human serum of gonadotropins (β-HCG) and progesterone (P) level increased significantly after treatment, and the treatment group two hormone levels were significantly higher than those in control group (P<0.05);41patients with IL-10level after treatment were significantly increased, and the treatment group IL-10level was significantly higher than the control group (P<0.05);41patients with TNF-α level after treatment are different rate reduce, after the treatment group was lower than before treatment (P<0.01), and the control group before and after treatment no obvious difference (P>0.05), but compared between the two groups after treatment of TNF-α level, no difference between the two groups (P>0.05);41patients of Th1(TNF-α)/Th2(IL-10) ratio in treatment all has different rate lower, including the treatment group before and after treatment had abnormal significant difference (P<0.01), and the control group before and after treatment no significant difference (P>0.05), the treatment group and control group, compared the treatment between after Th1/Th2ratio with exceptional significant difference (P<0.01).41patients out of the group conditions, analysis P,β-HCG, TNF-α, IL-10before and after treatment, the level of Th1/Th2before and after treatment, ratio of the kidney Yang before and after treatment and kidney Yin deficiency of integral correlation, found that patients before therapy serum P level and β-HCG level a positive correlation, after treatment two weeks after, both into not completely related; Patients before therapy serum TNF-α level and IL-10level into is related to the performance for each other and reduce or elevated status, after treatment two weeks after, both present a not completely related state; Before and after treatment serum Th1/Th2patients with kidney Yang ratio, kidney Yin deficiency syndrome is not fully present integral correlation.21cases treatment groups of patients, the existing in1has had the natural abortion,5patients have babies, delivery mode choice all cesarean section, neonatal no one death, neonatal weight:3360±155.72, Apgar,9.80±0.45, the rest of the15patients is now pregnancy to medium (20-27weeks),21patients there no one pregnancy complications;20control patients, the existing in5patients natural abortion, eight patients have babies, delivery method: choose a vaginal delivery in1,7cases choose cesarean section, neonatal no case was killed, neonatal weight3362.5±273.54, Apgar,9.75±0.46, the rest of the7patients is now pregnancy to middle-late stage (20-33weeks),20cases appear in1gestational diabetes, have babies.Two sets of patients pregnancy complication incidence, newborn babies, several live birth weight newborn Apgar score, etc. There is no difference.Conclusion:The results show:"ZHU YUN NING NO.1" can improve the serum progesterone (P), human gonadotropins (β-HCG) in the hormone in the content, for unexplained cause recurrent miscarriage have obvious curative effect. |
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