Comparison For Treatment Of B-cell Non-ho Dgkin Lymphoma Between R-CHOP Regimen And CHOP Regimen

OBJECTIVE To compare the eficacy and side-efects of R-CHOP regimen with CHOP regimen in treating CD20positive B-cell non-hodgkin lymphoma(NHL) by analyzing clinical features of patients in our hospital.METHODS We retrospectively analyzed64patients with CD20positive B-cell NHL diagnosed by the pathological and immunohistochemical features treated in our hospital.34cases in R-CHOP group were treated with R-CHOP while30cases in CHOP group were treated with CHOP.The efficacy and side-efects of these two groups were evaluated,and the patients were followed up t o assess their survival time and compare the one-year survival rate and two-ye ar survival rate of these two groups. The clinical data were analyzed by SPSS18.0.RESULTS The complete remission(CR)rate and overall response rate in R-CHOP group was58.8%(20/34)and88.2%(30/34),while40.0%(12/30)and60.0%(18/30) in CHOP group, respectively.The complete remission(CR)rate between the two groups had no statistical significance (P>0.05),while the overall response rate between the two groups had statistical significance (P<0.05). The one-year survival rate was90.9%and two-year survival rate was86.5%in R-CHOP group,while79.1%and64.7%in CHOP group,respectively,with statistical significance between the two groups(P<0.05). The major side-effect of the two groups was bone marrow suppression,other side-efects such as gastrointestinal reaction,elevated transaminase and alopecia also exist. Differences between the two groups had no statistical significance(P>0.05).CONCLUSIONS Compared with CHOP regimen, R-CHOP is more effective both on short-term remission rate and long-term survival rate in treating CD20positive B-cell NHL, while there were no additional side-effects,so it can be considered as the first-line therapy.