The Effects Of Different Types Of Calcium Channel Blockers On Lipid Modification Of Atorvastain

Background With the changes of human lifestyle, morbidity and mortality of hypertension and coronary heart disease is growing increasingly. Lipid lowering and antihypertensive therapy are important therapeutic measures to treat patients with hypertension and coronary heart disease. And it has become a new strategy for the treatment of hypertension. Atorvastatin and amlodipine, respectively, is the representation of drugs for cholesterol lowering agents and antihypertensive drugs. The former is a kind of statins that it has the most evidences based medicine for anti-atherosclerosis, the latter not only has good antihypertensive effect, but also evidence to suggest its anti-atherosclerotic effect. Interestingly, in clinical work, we also found that the both has a synergistic lipid metabolism. Herein, we reported whether other calcium channel blockers combined atorvastatin statins have this effect.Objective To evaluate the effects of different types of dihydropyridine calcium channel blockers on lipid modification of atorvastatin.Methods Take the method of prospective study, hospitalized patients with hypertension and coronary heart disease were given to check liver function and blood lipids and other circumstances. According to clinical conventional blood pressure and coronary heart disease treatment program, Regardless of whether they had taken lipid lowering drugs,and they were the object of observation as long as the Lipids does not meet the standard level, All patients are therefore correspondingly atorvastatin20mg/d. liver function, blood lipids, serum creatine kinase and other changes and adverse reactions were observed before treatment and after2weeks,4weeks,8weeks. After observation, groups were determined according to their antihypertensive treatment program:The amlodipine-based antihypertensive program is classified as Group A, and other dihydropyridine calcium channel blocker-based antihypertensive program is classified as Group B,the medication does not contain calcium channel blockers classified as group C.173cases were observed in group A,195cases of group B,140cases of group C. Lipid changes of each group were assessed.Results At week4,8the levels of TC and LDL-C in group A were lower than those in group B and C, and significant difference was found (P<0.05). Compared with group B and C, HDL-C in group A increased notably at week8after treatment (P<0.05).Compared with group C, the levels of TC, LDL-C and HDL-C in group B were not found significant difference at week2,4,8(P>0.05).Conclusion Amlodipine may enhance the effect of atorvastatin on regulating lipid profile,while other calcium channel blockers do not have this effect now.