Analysis Of Protein Components Of Skeletal Muscle From PM Patients And Related Reviews

Polymyositis (PM) is one of the main forms of idiopathic inflammatory myopathies(ⅡM), which contain Dermatomyositis (DM)、polymyositis (PM) and inclusion body myositis (sIBM). Like other IIMs,PM has a proximal muscle weakness,and the follow up of a high creatine-kinases level in spite of its possible normality.As to its pathological changes,it’s well known that there is a aggression of CD8+T cells beteween muscle fibers and a coexistence of muscle necrosis and regeneration.Generally speaking, muscle weakness of PM patients due to the muscle necrosis and inflamation.However, the ratio of Myosin and Actin(M/A),which represents the relationship of the two most inportant proteins associated with muscle contractions,may reveal a new explanation to the muscle weakness of PM. Generally speaking, muscle weakness of PM patients due to the muscle necrosis and inflamation.Here we used the SDS-PAGE to analyze the M/A of PM patients, and find that the mean M/A is0.6965±0.03380,compeared with the normal group of1.4838±0.04922,P<0.001. We also analyzed the corellation among M/A muscle fatigue and CK level.Besides,this paper is also a review of PM on the clinical presentations、...