A Study On The Expression Of DKK1and β-catenin In Several Solar Associated Skin Neoplasms

Objective：To investigate the expression and significance of DKK1andβ-catenin in the epiderm of normal skin，seborrheic keratosis，actinickeratosis，Bowen’ s disease and squamous cell carcinoma.And to discussthe relationship between the expression DKK1and β-catenin.Methods：Immunohistochemical staining was applied to detect the expressionof DKK1and β-catenin in paraffinum specimens of19cases of seborrheickeratosis,16cases of actinic keratosis,24cases of Bowen＇s disease and25cases of cutaneous squamous cell carcinoma,22normal skin specimenswere used for controlling.Results：DKK1expressed in cytoplasm In normal epidermis.The positiveexpression rates of DKK1in SK, AK, BD and SCC were respectively63.16%,50.00%,12.50%,8.00%.β-catenin expressed in cell membrane innormal epidermis.The abnormal expression rates of β-catenin in SK, AK, BD and SCC were respectively15.79%、56.25%、91.67%、96.00%.There is significant negative correlation between the expression of β-cateninand DKK1(r=-0.692,P=0.000).Conclusion：The Wnt signaling pathway may play a important role in the process ofepidermal neoplasms formation.The loss of DKK1may promote theabnormal expression of β-catenin through Wnt signaling pathway.