Correlations Of Hmgb1Expression With Vegf And Microvascular Density In Hepatocellular Carcinoma

Objective: To investigate the correlations of high mobility group protein box-1(HMGB1) expression with vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) in hepatocellular carcinoma (HCC) and its clinical significance.Methods:Western blot was performed in10HCC tissues and the corresponding adjacent-tumor tissues, and5normal liver tissues. Expressions of HMGB1, VEGF and CD34were detected with immunohistochemistry in37specimens of HCC tissues and the corresponding adjacent-tumor tissues, and10cases of normal liver tissues. The MVD was calculated using CD34antibody as an endothelial marker.Results:Expression of HMGB1appeared at a high level compared to adjacent-tumor tissues and normal liver tissues. HMGB1expression was significantly correlated with the tumor size and the portal venous invasion. HMGB1expression was positively correlated with VEGF expression and MVD in HCC(r=0.544, P=0.001; r=0.672, P＜0.05).Conclusion:Upregulation of HMGB1and VEGF are involved in the angiogenesis of HCC, and HMGB1may be a therapeutic target for angiogenesis in HCC...