The Relationship Among Pregnancy Associated Plasma Protein-a And Coronary Heart Disease

Background：Coronary heart disease is a kind of frequently-occurringand common disease, may present clinically according to a variety ofinspection results, such as biochemical markers of myocardial necrosis,symptoms during an episode of electrocardiogram in diagnosis of coronaryheart disease, treatment, have greatly improved. In order to improve thediagnosis and treatment of care is further improved, and the patient’scondition judgement, treatment, and prognosis of further understand. Atpresent domestic and foreign research on PAPP-A more, think PAPP-A mayin coronary heart disease, the development process plays an important rolein important, and obtained a lot of research conclusion. This researchmainly studies PAPP-A may not from rupture of a plaque or unstableplaques release.Objective：to validate PAPP-A may be composed of heparin induced invivo PAPP-A storage pool generation.Methods：The se rum levels of PAPP-A in13case swith acute coronarysyndrome (ACS),12cases with stable angina pectoris (SA) and There aresymptoms of chest pain and coronary angiography in diagnosis of coronary heart disease patients with no10, Dual atrioventricular nodal pathwayradiofrequency ablation in the treatment of patients with10. All patients inthe first days after admission to the determination of PAPP-A, angiographyin patients with intravenous injection of heparin by15min,30min,45min,60min PAPP-A determination; stent implantation in the treatment ofpatients, the additional injection of heparin after15min,30min,45min,60min were measured in peripheral blood and coronary arterial bloodPAPP-A value.Results：(1) coronary angiography patients using heparin within1hours after, ACS and SPA underwent stent therapy, with100iu/kgsupplemental heparin within1hours, three patients with blood groupPAPP-A concentration and then decreased gradually.(2) ACS and SPA inthe detection of patients at each time point, peripheral blood PAPP-Aconcentration and PAPP-A concentration had no significant differenceConclusion：(1) Heparin may be induced in vivo release of PAPP-Astorage pool.(2)Coronary artery disease in patients with peripheralPAPP-A elevation may not by atherosclerotic plaque release.