Gastrointestinal Neuroendocrine Tumors: A Clinical Study Of25Cases

Objective To analysis the clinical characteristics and treatmentmethods of the gastrointestinal tract neuroendocrine tumors, in order todiscuss the diagnosis and treatment of these diseases.Methods The clinical data of25cases with gastrointestinalneuroendocrine tumors were analyzed retrospectively.Results In this25cases, the sex ratio of male and female is1.27:1,and the average age was56.8years. The clinical manifestations of eachcase were different, about68%patients have symptoms but32%weresilence. And there was one patient have liver metastasis. The mainmanifestations were epigastric dull ache, ventosity, jaundice, emaciation,changing of the habits of defecation, hematochezia, melena and so on. Butall of them without carcinoid syndrome. Through the conventional medicalexamination, one patient show jaundice, six cases with acute abdominalpain, abdominal deep tenderness of three cases, one case have pain whenknock at the area of liver， abdominal mass in five cases and found mass orpolyp of six cases by digital rectal examination. Do abdominal ultrasonic orabdominal CT examination, tip malignancy in ten cases, one of themreceived MRI examination and considered ampulla and the head of pancreas lesions. Nineteen cases of this group, do digestive endoscopyinspection and histologic examination routinely in preoperative, ten caseswere diagnosed and have higher risks of two cases，even diagnosed onecolon carcer. Postoperative diagnosed in six patients, and postoperativefound one case by accident when do histopathologic examination. Allexcept one patients of this group failed to operation due to other reasons,the others all chosen corresponding surgery according to the lesions of thetumor. After underwent radical resection, if there were evidence of lymphnode metastasis, patients should receive FOLFOX4scheme1to4times asconventional chemotherapy. One duodenum NET patients also joint use ofsomatostatin analogs octreotide LAR30mg every4weeks. One patientwith rectum NET using Gamma rays to treat liver metastases. Seventeenpatients were followed up5to36months, thirteen patients are survivalwithout distant metastases evidence. The clinical manifestations ofGE-NETs has evident heterogeneity, so the diagnose rate were low. And themain diagnosis method is digestive endoscopy, all manner of surgery is themost important way of treatment. After appropriate treatment, patientprognosis is good.