Etiology And Clinical Characteristics Of1048Liver Cirrhosis Cases

Objective: Retrospective analysis the etiology, clinical features andprognosis of hospitalized patients who suffered from liver cirrhosis in thearea of Chongqing, which may be useful to make proper methods forpevention and treatment chronic hepatitis B, improvement clinicaloutcomes and life quality, and prolongment life time.Methods: Clinical data, gendar, age, etiology and complications ofthe confirmed liver cirrhosis patients from July of2005to July of2010inthe second affiliated hospital of Chongqing Medical University wereanalysed retrospectively. We also investigated the condition of anti-virustreatments in HBV related cirrhosis patients and their clinical outcomes,and tried to make better effective measures to prevent development ofcirrhosis and improve life quality of the patients.Results: Data of1048patients,837male cases,211female cases wereincluded. The ages of these patients were from11to85years old, and thepatients with the age of31-69years old were more common. Among them,917(87.5%) cases were caused by hepatitis B virus infection.30（2.86%) cases were caused by cryptogenic factors.24(2.29%)cases had mixedetiology which caused by alcohol and hepatitis B virus.13(1.24%) casesby Cholestatic bilirubin,12(1.14%) cases by hepatitis C virus infecton,11(1.04%) cases by autoimmune liver disease,10(0.95%)cases by alcoholicdamage. Other factors induced liver cirrhosis were rare includingBudd-Chiari syndrome, hepatolenticulra degeneration (wilson diseases) andno-alcoholic fatty liver cirrhosis.656of1048liver cirrhosis cases(62.6%)presented different complications, including210cases （32.01%）spontaneous bacterial peritonitis,165cases （25.16%） uppergastrointestinal bleeding, and127cases（12.11%）primary hepatocelluarcarcinoma with the rate of98.43%caused by only the infection of hepatitisB virus,2.68%by both alcohol consuming and hepatitis B virus infection.Only4patients in the liver carcinoma group received antiviral therapybefore admission.Among917HBV-related cirrhosis cases, only14.72％of whom hadreceived antiviral therapy before admission.711cases had been testedHBV-DNA quantity in the hospital,110cases with HBV-DNA below1×103copies/ml, and601cases above1×103copies/ml, amony them,278cases with the level of HBV DNA quantity between1×103-5copies/ml,323cases above1×105copies/ml.Only58cases with compensated livercirrhosis and270cases with decompensated liver cirrhosis acceptedantiviral therapy. However approximately45%of the cases met the criteria of antiviral therapy did not like to accept antiviral treatment owing tovarious reasons.51cases in this study died of complictions of upperdigestive tract hemorrhage (33.33％), hepatic encephalopathy(33.33％),and spontaneous bacterial peritonitis(17.64％), the most three commoncomplications.Conclusion: The data showed that the main cause of cirrhosis wascaused by hepatitis B virus infecion, cryptogenic factors, mixed injures byalcohol and hepatitis virus, hepatitis C virus infection. The canceration rateof cirrhosis in this group was12.11%. Only35.76%of the HBV relatedcirrhosis patients accepted antiviral therapy, which indicated that theimportance of antiviral therapy wasn’t accepted widely by the majority ofthe patients．Patients with hepatitis B virus related cirrhosis should be givenantiviral treatment as long as virus was postive. Nucleos(t)ides analoguescould be used as early as possible which may improve clinical prognosis.