Several Biochemical Indices Based On Roc Curves In Diagnosis Of Intrahepatic Cholestasis Of Pregnancy

Objective:To evaluate TB, DB, ALT, AST, r-GGT, TBA and CG for diagnosis of ICP by receiver operating characteristic (ROC) curves.Methods:Draw ICP patients and normal control group, mild and severe ICP patients were compared with a ROC curves, evaluation each biochemical indicators and the related degree between ICP.Results:For ICP group and in normal control group:TB, DB, ALT, AST, r-GGT and TBA of the AUC respectively were0.693,0.821,0.781,0.846,0.745, and0.831, the best boundary13.65umol/L,2.85umol/L,51.5U/L,44.5U/L,22.5U/L,11.25umol/L. In China ICP diagnosis guide for gold standard, mild and severe ICP group:TB, DB, ALT, AST, r-GGT,TBA and CG of the AUC respectively were0.819、0.857、0.809、0.812、0.665、0.787and0.870,the best boundary10.45umol/L、5.35umol/L105.5U/L、97.5U/L、23.5U/L、19.25mol/l、42.7umol/l.Exclude glycocholic acid, the rest index is still in China ICP diagnosis guide for the gold standard, mild and severe ICP group:TB, DB, ALT, AST, r-GGT and TBA of AUC respectively were0.861,0.892,0.828,0.846,0.647,0.809, and13.35, the best boundary13.35umol/L,5.65umol/L,137.50U/L,97.50U/L,28.50U/L,32.60umol/L.And by table6,9and clinical experience suggests ICP is a more cause disease, not only by individual index diagnosis ICP and distinguish between light/severe ICP, need to be more comprehensive consideration of the index to do comprehensive accurate, increase its sensitivity and specificity.Conclusion:Based on the analysis of the ROC curves, these a few biochemical index to the diagnosis of ICP there is meaning, We suggest that in the middle-late for pregnancy appears itching, or with different degrees of jaundice in pregnant women, in the exclusion of skin disease cause itching and viral hepatitis and other liver diseases caused by the abnormal liver function, TBA>11.25umol/1can diagnosis for the ICP.And for the ICP indexing, from the table8and table9comprehensive consideration, suggest to TBA>32.60umol/1, or ALT>137.50U/l, or AST>97.5U/l, can consider diagnosis for severe ICP.