Clinical Use Of Serum Human Epididymis Secretory Protein4

Early detection for ovarian cancer is one of the most challenging tasks all the time. Among those markers which are wildly used in clinical, CA125shows low specificity and badsensitivity in early stage of ovarian cancer, which made its use in clinical limited. HE4is considered to be the most promising tumor marker for ovarian cancer detercion and its clinical performance deserves attention. Objective To evaluate the clinical use of HE4in ovarian cancer diagnosis, monitoring and prognosis. Analyze HE4cl inicopathological variables. Evaluate the use of HE4in endometrial carcinoma diagnosis. Methods①445cases were collected and serum HE4were measured double blindly.②12possible clinicopathological variable for serum HE4level were evaluated to find the connection between them.③Follow-up studies among16patients with ovarian cancer were performed to detect the FIE4and CA125levels.④Collect38endometrial carcinoma cases and determined their serum HE4levels. Results①The median levels of HE4were significant higher in ovarian cancer group(306pmol/L) than other groups. Positive rate of HE4was lower than that of CA125, and specificity of HE4was higher. Combination detection of CA125and HE4can improve diagnosis sensitivity.②FIGO staging, histology, pelvic involvement. peritoneal cytology, lymph node involvement status have highly signicicant impact on serum HE4level in ovarian cancer. Menopause, childbearing history impacts are significant. Age, smoking, BMI and family history contribute none to HE4levels.③HE4level changes are consistent with disease progress and are3to6months prior to CA125changes. High levels of HE4indicate bad prognosis in ovarian cancer.④HE4levels range from32pmol/L to585pmol/L with median level185pmol/L in38endometrial carcinoma cases。 which were highly significant than those of healthy group and benign ovarian disease group. Conclusion HE4can be used as a marker for ovarian cancer prodiction,as well as in progression and prognosis. Combine HIM with CA125can improve ovarian diagnosis. HE4level is varied with several clinicopal ho logical factors. Serum HE4is a promising tumor marker in endometrial carci noma.