The Experimental Study Of5-Fu Sustained-release Implant In Local Administration On Ivansplanted Breast Cancer Of Balb/c Mice

Objective: To compare of the efficacy of5-Fu sustained-release implant in localadministration and5-Fu chemotherapeutics on transplanted breast cancer of Balb/cmice.Methods: Fifty transplanted breast cancer of Balb/c mice were randomlydivided into5groups，ten in each group. Group A and B were treated withperi-tumoral implantation of5-fluomuracil implants and the dose of5-fluorouracilwas200and100mg／kg, respectively．Group C were treated with peri-tumoralinjection of5-fluomuracil solution and the dose of5-fluorouracil was200mg／kg，Group D were treated with injection of5-fluomuracil solution intra-abdominal andthe dose of5-fluorouracil was200mg／kg， Group E did not receive anytreatment．growth curve was plotted for changes in tumor volume，the weight of thetumor was measured and tumor inhibition rate was calculated.Results:1. The growth curve Was mild in group A and B and steep in group C，D and E，There were statistical differences in tumor volume between groups A and Band other groups and there were no statistical differences in tumor volume amonggroup C，D and E．After12days，tumor inhibition rate was50.43％in group A，41.64％in group B，27.57％in group C，and22.87％in group D；2.There were statisticaldifferences in inhibition rate between group A，B and C，D(P<0．05)；3. There werestatistical differences in ErbB2expression rate between group A，B， C andD(P<0．05).Conclusion: Delayed-release5-fluoroumcil implants can effectively inhibittumor growth．...