The Impact Of Different Activities On The Articular Cartilge After ACL Injury

Object:this study aims to research the effects of different activities on articular cartilage after anterior cruciate ligament injury in rabbits, Methods:Twenty four male New Zealand white rabbits (about three-months-old) were randomly selected one side of the knee joints to the anterior cruciate ligament transaction and divided into four groups averagely after operation:free feeding group, immobilization group, continuous passive movement group, and immobilization group after continuous passive movement. After Four weeks. The lateral femoral condylewere researched to observe the general morphology,IL-1β、MMP-1expression in the articular cartilage. Rusult:the cartilage surface of each group are different degrees of cartilage degeneration. IL-1β and MMP-1expression in the articular cartilage of continuous passive motion group and immobilization group after continuous passive movement was significantly lower than free feeding group (p<0.01) and the immobilization group (p<0.01), IL-1βand MMP-1expression in the articular cartilage of immobilization group was higher than free feeding group, but the differences is not significant The difference of the IL-1β and MMP-1expression in the articular cartilage between the continuous passive motion group and immobilization group after continuous passive movement. Conclusion: After anterior cruciate ligament injury, the cartilage degeneration is inevitable, continuous passive motion can reduce the expression of IL-1β and MMP-1in the articular cartilage, Slow Down the Cartilage Degeneration, and lay the foundation for anterior cruciate ligament reconstruction.