The Study On The Relationship Between Sleep Disordered Breathing And Coronary Heart Disease

Objective：Sleep disordered breathing（SDB）, expressed as obstructive sleep apnea syndromein the past, refers to the repeatedly apnea and hypopnea during sleep,leading to a fall inoxygen saturation and sleep fragmentation。Coronary heart disease(CHD) as one of themost serious diseases to human health，has given our country a heavy burden onpeople’s health and the social construction. Study on the relationship between CHD andSDB has been going on for decades.Study on the characteristics of SDB in the patientswith cardiovascular disorders is not much. In this area of study is still in the early stagein China. The aim of this study was to investigate the prevalence of SDB and itsrelationship to coronary heart disease through a cross section of case-control study.Methods：Totally206patients have come from the Department of cardiovascular of ShanghaiEast hospital during2010.10-2012.2. All of them successfully conducted the night ofsleep monitoring and coronary angiography. All cases according to the CAG result andclinical data analysised the prevalence of coronary heart disease and control groups ofSDB. and analysised the relationship between risk factors and coronary heartdisease.Depending on whether you with SDB or not, lesions and Gensini score systemanalysised the relationship between SDB index and the severity of coronary arterystenosis.Results：1. In patients with coronary heart disease Group (n=115) the prevalence of SDB is62.5%, significantly higher than the control group (n=91)49.5%,P=0.024; As a result variable of coronary heart disease, multivariate Logistic regression analysis showed thatAHI(OR=1.466,P=0.014),age(OR=1.845,P=0.004),male(OR=2.165,P=0.028),smoking(OR=2.778,P=0.004),Hypertension (OR=2.042,P=0.050) were selected for theregression equation ultimately (χ2=38.805,P<0.01).2. The BMI of coronary heart disease with SDB was significantly higher than thecontrol group (27.77±2.88,25.91±3.16,P=0.002), but the difference of the Gensiniscore was not statistically significantly (P=0.438). Divided the patients with SDB intonone, light, medium, heavy groups, The Gensini scores of each group had no significantdifferences (F=0.810,P=0.049). The medium and heavy SDB group (2lesions,3lesions)in prevalence rates of multiple-vessel lesions was significantly higher than mild SDBGroup (χ2=5.672,P=0.017). ODI3, ODI and ESS scores was positively correlated withGensini score（sr=0.137,0.139,0.13,P=0.049,0.047,0.025).Controlled the age ODI4arestill associated with Gensini scores (r=0.156,P=0.025).Conclusions:1. disordered breathing ()The prevalence rate of SDB is very high which should bepay more attention.2. Fat in patients with coronary heart disease complicated with SDB wasSeemingly easy.3. AHI may be an independent risk factors for coronary heart disease.Eelevatedeach severity1level of SDB, the risk of coronary heart disease increased relative46.6%.4. Moderate and Severe SDB is more likely to occur in patients with multi-vesselcoronary artery disease.There was lower correlation between Gensini score and AHI，ODI which need pending further study.