Changes To The Malignant Tumor Patient’s Ocular Surface Before And After Initial Chemotherapy

Objectives To investigate the changes to the ocular surface of patientswith malignant tumors before and after initial chemotherapy.Methods Sixty patients were diagnosed of malignant tumors. The statusof their ocular surface was evaluated in an observational case series, with thehelp of dry eye questionnaire (DEQ), breakup time (BUT), Schirmer I test(SIt), fluorescein staining (FL), tear ferning test (TFT), lissamine greenstaining (LG), impression cytology of conjunctiva (IC), one week before andafter initial chemotherapy.Results After initial chemotherapy, the most common symptoms afterinitial chemotherapy were vision blur, dryness and discomfort. BUT and SItwere shorter, scores of FL and LG were increased, grades of TFT were lowerand conjunctival goblet cells were less (all P<0.05). Gender, type of tumor orpatients age did not affect changes to the ocular surface before and after initialchemotherapy.Conclusions Chemotherapy could impose toxic or side effects on theocular surface of patients with malignant tumors, which might lead to dry eyeor worsen the progression of dry eye. Attention should be paid to the health ofocular surface during chemotherapy, in order to strengthen the quality of lifeof patients with malignant tumors.