The Expression And Clinical Significance Of Costimulatory Molecules B7-H1and B7-H3in Non-small Cell Lung Cancer Tissue

Objective: To detect the expression of B7-H1and B7-H3in non-small cell lungcancer tissue and study the significance of costimulatory molecules B7-H1and B7-H3innon-small cell lung cancer tissue.Methods:The tissue of the non-small cell lung cancer patients who were previouslyuntreated and had surgical resection were collected in the Department of CardiothoracicSurgery of the First Affiliated of Soochow University of85cases. B7-H1and B7-H3expression was detected by immunohistochemistry(IHC) and the clinical data parametercorrelation was analyzed with statistic software.Results:1．There are different levels of expression of B7-H1and B7-H3in non-smallcell lung cancer tissue，the expression was mainly located in cytoplasm and cell membrane,or both exist.Although the adjacent tissues and distal lung tissue there are also theexpression of B7-H1and B7-H3, its expression levels in cancer tissues were significantlyhigher（p<0.01）.2. The expression of B7-H1was related to the tumor cells in lymph nodemetastasis，but the expression of B7-H1was not associated with sex、age、pathologicaltype、differentiation degree、tumor size、clinical stage and history of smoking（p>0.05）；The expression of B7-H3was related to the clinical stage and tumor cells in lymph nodemetastasis，but B7-H3was not associated with sex、age、pathological type、differentiationdegree、tumor size and smoking（p>0.05）.3．The expression of B7-H1and B7-H3proteinin non-small cell lung cancer tissues was positively correlated （rn=0.217，p<0.05）.Conclusion:1．B7-H1and B7-H3expression of the protein both in non-small cell lung cancer tissue was significantly higher than the adjacent tissues and distal lung tissue.2.The expression of B7-H1was related to the tumor cells in lymph node metastasis;theexpression of B7-H3was related to the clinical stage and tumor cells in lymph nodemetastasis.3.B7-H1and B7-H3protein expression are relevant, both to participate innon-small cell lung tumor cell invasion and metastasis.4.B7-H1and B7-H3promoteslymph node metastasis,and the biology mechanism needs further study.