Study Of Correlation Between Level Of Plasm Soluble ST2and Degrees Of Coronary Artery Stenosis In Patients With Acute Myocardical Infarction

AIM:The present study was designed to investigate the association between plasm concentrations of the soluble interleukin-1receptor family member ST2(sST2) and the degree of coronary artery stenosis in patients with acute myocardical infarction (AMI).METHODS:Plasm soluble ST2levels were measured with enzyme-linked immunosorbent assay (ELISA) in44AMI patients within12hours of the onset. The levels of coronary stenosis were assessed by Gensini scores and numbers of diseased vessels were counted. The association between plasm soluble ST2level and coronary artery stenosis degree was analysed by SPSS software.RESULTS:In AMI patients, the plasm sST2was increased significantly in high Gensini scores subgroup (P<0.001) and a positive relation was found between sST2levels and Gensini scores (r=0.772, P<0.001). The plasm sST2level was also significantly higher in patients with multivessels compared with single vessel (P<0.01).CONCLUSION:The level of plasm soluble ST2was positively correlated with severity of coronary stenosis and it may predicte the degrees of coronary stenosis in AMI patients.