Effects Of Dexmedetomidine On Perioperative Inflammatory Response And Oxidative Stress In Patients Undergoing One Lung Ventilation

Objective:To investigate the effects of different dosages of dexmedetomidine on perioperative inflammatory response and oxidative stress in patients undergoing one lung ventilation (OLV).Methods:Thirty-six ASA I or II patients aged43-72yr weighing50-78kg scheduled for esophagectomy were randomly divided into3groups(n=12each):control group (group C), low dose dexmedetomidine group(group D1) and high dose dexmedetomidine group (group D2). Dexmedetomidine1μg/kg was injected iv over10min before anesthesia induction, and then was infused at a rate of0.2μg-kg-1·h-1(group D,) or0.5μg-kg-1·h-1(group D2)until30min before the end of operation. Group C received the equal volume of normal saline. Blood samples were collected before anesthesia induction(T0), immediately before OLV (T1),30min (T2),90min(T3) of OLV,30min after lung inflate (T4) and2h after operation (T5) for determination of serum TNF-a, IL-6, MDA concentrations and SOD activity.Result:Compare with To, serum TNF-a, IL-6concentrations were increased at T3-T5, MDA concentration was increased, and SOD activity decreased at T4,T5in the3groups(P<0.05). Compared with group C, serum TNF-a, IL-6concentrations were decreased at T3-T5, MDA concentration was decreased, and SOD activity increased at T4,T5in group D2(P<0.05).There was no significant difference in the indexes maintained above between groups C and D,(P>0.05).Conclusion:Dexmedetomidine (0.5μg-kg-1·h-1) can reduce inflammatory response and oxidative stress in patients undergoing OLV.