Three Cases Report Of Acute Panantonomic Neuropathy And Literature Review

To improve understanding and treatment of acute panantonomic neuropathy for clinicians, especially for neurology clinicians. Method:Reported three cases of acute panantonomic neuropathy, reviewed literature at home and abroad to analysis the etiology, pathogenesis, diagnostic criteria and treatment of the disease. Results:We have received three patients who were diagnosed as acute panantonomic neuropathy. Their symptom includes autonomic nerve dysfunction on pupil, sweat glands, gastrointestinal tract, sphincter, cardiovascular and so on. It indicated that the sympathetic and parasympathetic postganglionic cholinergic transfer impaired exited. The electromyography prompted neurogenic damage, conduction velocity and amplitude reduction. The result of lumbar puncture showed normal cerebrospinal fluid pressure, elevated CSF protein as well as normal white blood cell count. Corticosteroids or intravenous immunoglobulin globulin therapy and symptomatic and supportive treatment were given. Prognosis of two patients is good, but the other one is poor.Conclusion:Acute panantonomic neuropathy are often an acute manufacture. There is always an infection before the onset of this disease. The clinical manifestations includes a wide range of autonomic function impairment, neurogenic damage on electromyography and maybe elevated cerebrospinal fluid protein. Corticosteroids or intravenous immunoglobulin globulin therapy would be effective.