| Objective:To observe the perfusion features with quantitative assessment,in order to investigate the clinical significance of contrast-enhanced ultrasound(CEUS) in the diagnosis of severe esophageal varices.Material and Method:Eleven patients with a endoscopy or upper gastrointestinal proved diagnosis of severe esophageal varices, and the control group who consisted of thirteen patients without a history of chronic liver disease both underwent conventional ultrasound and CEUS. A Philips iU-22ultrasound scanner with L2-5probe,0.06-0.08mechanical index and contrast pulse sequence imaging was used. Patients were asked to be on an empty stomach with supine position, exposing upper abdomen.Firstly, the esophageal was scanned with conventional ultrasound. The thickness, gradation and echo were observed. Secondly, the blood flow of the esophageal was observed with Color Doppler Flow Imaging(CDFI). Finally, select the best section and switch to CEUS.Bolus SonoVue was injected via antecubital vein,followed by a flush of5ml nomorl saline solution. Dynamic imaging was stored and analyzed with QLAB software. Parameters including the thickness,arrival time (AT), time to peak (TTP), derived peak intensity (DPI), and slope rate of ascending curve(A) were observed.All the data obtained were analyzed by SPSS16.0software.T-test was used to compa re the difference between two groups. P values of0.05or less were considered to indie-ate significant differences.Results:1.The thickness were significantly thicker for the patients with severe esophageal varices,compared with values for the control group.2.Compared with the control group,AT and TTP were significantly extended. Nevertheless, there were no significant differences in the value as DPI and A between the patients with severe esophageal varices and the control group, while the DPI and A value was reduced.Conclusion:CEUS may serve as a new and a valuable means for evaluating the severe esophageal gastric varices. |
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