Expressions And Significance Of Bcl-6and Ki-67in Diffuse Large B-cell Lymphoma

Objective: To investigate and study the expressions and significance of bcl-6and Ki-67in diffuse large B-cell lymphoma (DLBCL) with the immunohistochemistry technique.Method:Immunohistochemical Maxvision method was used to detect the expressions of bcl-6and Ki-67in the tissues of90cases of diffuse large B-cell lymhpoma and20cases of reactive hyperplasia of lymph node (RH). And the statistic data were performed by the SPSS16.0software.Results:The positive expression rate of bcl-6and the high expression rate of Ki-67in diffuse large B-cell lymphoma were both significantly higher than those in RH. The positive expression rate of bcl-6in diffuse large B-cell lymphoma was54.44%(49/90), and the positive expression rate of bcl-6in RH was15%(3/20)(X2=10.214, P=0.001). There were correlations between bcl-6expression and Ann Arbor clinical stage, LDH, B symptoms, or Hans classification (X2=5.257,5257,4.704,16.024respectively, all P<0.05). The high expression rate of Ki-67in diffuse large B-cell lymphoma was80.00%(72/80), and the high expression rate of Ki-67in RH was20%(4/20)(X2=27.585, P=0.000). There were correlations between Ki-67expression and Ann Arbor clinical stage, International Prognostic Index (IPI) or recent effect (X2=5.889,6.451,6.024respectively, all P<0.05). In addition, in the Ki-67high expression group, the recent clinical results of Ki-67≥90%patients were worse than those whose Ki-67were between50%and90%(X2=6.712, P<0.05).Conclusion:There were significant correlations between the aberrant expression of bcl-6and Ki-67and Ann Arbor clinical stage, IPI and Hans classification. The expressions of bcl-6and Ki-67may provide important information for the clinical therapy and prognosis of diffuse large B-cell lymphoma.