| Objective To study the factors influencing therapeutic effect of131I in treating Graves disease in elderly.Methods All the278patients over60years old with Graves’hyperthyroidism who received131I therapy between2006and2011were intensively followed up,among which,220(mean age65.35±5.00years,including50males and150females)were successfully followed up. Curative effects of all patients were judged only in a single visit, each patient was evaluated once for therapeutic efficacy. The assessment of the therapeutic effect was made according to cure (including hypothyroidism)and not-cured(including improvement and ineffectiveness) after131I therapy.220patients were divided into5groups according to the follow-up time, Chi-square test was used to analyze the curative effect with131I therapy of the5groups. Stepwise logistic regression was used to analyze the influencing factors of efficacy with131I therapy.Results①After more than1years,72.7%of the cases were cured,25.4%were improved, and1.8%were unchanged.②The results of multivariate analysis showed that the age of patients, the weight of thyroid,24h-RAIU, and the giving131I dosage/g thyroid tissue were correlated to not-cured. The logistic regression equation was statistically significant.Conclusions①Radioactive131I is a very effective treatment method for Graves’disease in elderly patient.②Thn older patients and those patients whose thyroid weight is bigger than60g,24h-RAIU is higher, the given131I dose per gram tissue of thyroid should be increased,in order to increase the curative ratio. |
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