Risk Factors And Prognosis Of Contrast-induced Nephropathy With Chronic Renal Dysfunction

ObjectiveTo investigate the risk factors, clinical characteristics, and prognosis of co ntrast-induced nephropathy (CIN) in patients with chronic renal dysfunction aft er Coronal Artery Angiography.MethodsWe retrospectively analyzed 184 patients with chronic renal insufficiency who received coronary angiography in our hospital.CIN was found in 19 patie-nts, after angiography. We compared the clinical characteristics, medication dur-ing angiography day, volume of contrast-medium, as well as renal function c-h anges before and after angiography in patients with (16 cases) and without (3 cases) CIN. The CIN patients were further divided into two groups function non-recovery group (3cases), and difference between these two groups was a-nalyzed.ResultsIn all the patients, there were more cases with old age, hypertension, and type 2 diabetes in CRI group than the other group (p<0.05). Patients with Chest pain, the merger of CRI in patients with coronary heart disease was significantly higher than the non-CRI group (P<0.01). CRI group of multi-v essel disease, diffuse disease compared with non-CRI patients with more comm on.All of the patients with normal renal function CIN was 3.7%, and all r enal dysfunction in patients with the incidence of group CIN was 25.0%. CIN incidence rate in patients with CRI was 18.2% in patients with CRI whose Scr during 132.6μmol/L to 168μmol/L, compared the 31.3% in patie-nts with the scr>176.8μmol/L. The average amount of contrast agent was (159.8+69.7) ml in patients with CIN. There was significant difference co-mpared with the NON-CIN group (p<0.05). The level of Scr and Ccr we re higher in 3 days later than the day before CAG, but not in the urine v olume. In 15 days later, the level of Scr was decreased to the level befor-e the CAG in 16 cases.Conclusion(1) CAD incidence of CRI patients with chest pain is higher than in non-CRI patients with chest paim, and often complicated with severe coronary arter-y disease.(2) Higher volume of contrast-medium and Scr level is a risk factor of C-IN in patients with chronic renal dysfunction.Pre-angiography Scr level and th-e contrast-medium volume are correlated with the prognosis of CIN in such p-atients.