Select Analysis On Congenital Heart Diseases Pedigree In Guangxi

Objective To provide the reference materials for the monitoring and intervention of the CHD genetic research.Methods140patients of CHD who were diagnosed at least in county hospital with their relatives were involved to the investigation of their age, sex, nationality, diseases, etc. by completing the questionnaire. Peripheral blood was extracted for DNA detection, and drawn graph of pedigrees with high incidence. Each patient is the one nuclear family, and more than two patients will be defined to pedigrees with high incidence.Results the Male patients took the parts of57.86%(81/140) slightly higher than the women of42.14%(59/140), but no significant difference between them (P>0.05); Ventricular Septal Defect(VSD)51.43%(72/140) with a higher incidence followed by Atrial Septal Defect (ASD)23.57%(33/140).49families were high incidence in140nuclear families(35.00%). The diseases of the relatives were no statistical difference with their probands(P>0.05),even15families were consistent30.61%(15/49).Conclusions The research shows that CHD has familial aggregation phenomenon, while the relatives were not exactly with the same disease as their probands. And genetic factors play an important role in the morbidity of CHD.