The Research About Expression Of ZHX2and Its Clinical Pathological Significance In Colorectal Carcinoma

Objective:To detect the expression of zinc-fingers and homeoboxes2(ZHX2) protein in colorectal carcinoma, and to analysis the relationship the expression of ZHX2protein with p53and survivin in colorectal carcinoma. And then explore the role of ZHX2in the occurrence and development of colorectal cancer. Methods:(1) Immunohistochemistry was used to detect the expressions of ZHX2、p53and survivin protein in73colorectal carcinoma tissues and their corresponding noncarcinoma mucosa tissue.(2) The results about the expressions of ZHX2、p53and survivin protein were analyzed by combination with the clinical and pathological data of the patients.(3) It was performed to analyzed the relationship expression of the p53and survivin protein with ZHX2. Results:(1) The positive rates of ZHX2in colorectal carcinoma samples and noncarcinoma tissue were82.2%(60/73) and 94.5%(69/73), respectively. The difference between the rates was significant(P <0.05).(2) It showed significant correlation with the tumor location and the degree of differentiation(P<0.05). However, no correlation was revealed between ZHX2expression and the gender, age, tumor size, depth of invasion, lymph metastasis and the Dukes stage (P>0.05). Through the follow-up the73colorectal cancer cases, the result of the survival Analysis was that the median survival time of ZHX2(-) group was55.3months and ZHX2(+) was24.7months. The survival time of ZHX2(+) group was longer than the ZHX2(-) group (P<0.05).(3) The positive rates of p53and survivin in colorectal carcinoma samples were72.6%(53/73)、52.1%(38/73), and in noncarcinoma tissue were38.4%(28/73)、20.5%(15/73).About p53expression in colorectal carcinoma, it showed significant correlation with the lymph metastasis and Dukes stage(P<0.05). However, no correlation was revealed between p53expression and the gender, age, tumor size, depth of invasion, tumor location and the degree of differentiation(P>0.05). About survivin expression in colorectal carcinoma, it showed significant correlation with the degree of differentiation(P<0.05). However, no correlation was revealed between survivin expression and the gender, age, tumor size, tumor location,depth of invasion, lymph metastasis and the Dukes stage (P>0.05).(4) In colorectal cancer, There were no significant correlation between ZHX2and P53(r=0.082, P=0.491>0.05), as same as the relationship between ZHX2and Survivin (r=0.123, P=0.300>0.05). the positive rates of p53and survivin in the ZHX2(+) group were73.3%(44/60)、55.0%(33/60),the difference between the rates was no significant(P>0.05); and in the ZHX2(-) group were69.2%(9/13).38.5%(5/13), the difference between the rates was no significant(P>0.05). Conclusion:(1) As a transcription inhibitor, ZHX2may be involved in tumorgenesis and progression of colorectal carcinoma which contribute to the prognosis of patients.(2) Respectively, ZHX2, p53and Survivin may had their possible pathways during the occurrence and development of colorectal cancer.