Effects Of Continuous Renal Replacement Therapy On Cell Immunity Function In Patients Of Icu With Sepsis

Objective:To explore the effects of continuous renal replacement therapy on cell immunity function and outcome in the patients with sepsis.Methods:Sixty-two patients with septic in the department of ICU of the first Affillited Hospital of Guangxi Medical University and acute APACHE II scores between15and30. Patients with tumor, organ transplantation, chronic end-stage diseases and those who had used immunity inhibitor in recent3months or hormones were excluded. The patients were devided into two groups:CRRT group (n=26) and control group (n=26). Patients in CRRT group were treated with continuous renal replacement therapy for3days in adddition to the administration of broad-spectrum antibiotics to all patients.The levels of T lymphocyte subtype were determined on the day before CRRT、3and7.At the same time the APACHE II scores were recorded. According to the APACHE II scores,the CRRT group were divided into group A(15-20,10patients)、 group B(21-25,8patients) and group C(26-30,8patients), and their levels of T lymphocyte subtype were also determined.Results:Compared with the control group(21.7±5.4d), the CRRT group’s (15.5±6.2d) length of ICU stay were decreased. There was statistically significant difference in the length of ICU stay of the CRRT group(P<0.05).In the CRRT group, the levels of CD3+,CD4+and the ratio of CD4+/CD8+had already increased obviously from the third day(all P<0.05);The APACHE II scores had increased obviously in the7th day(P<0.05).Compared with the control group at the same period,the levels of CD3+,CD4+and the ratio of CD4+/CD8+had already increased obviously from the third day(all P<0.05); The APACHE II scores had increased obviously in the7th day(P<0.05).In the group A,the levels of CD3+,CD4+and the ratio of CD4+/CD8+had already increased obviously from the7th day(P<0.05or P<0.01); In the Group B, the levels of CD3+and the ratio of CD4+/CD8+had already increased obviously from the7th day(P<0.05); In the Group C, the levels of CD3+and the ratio of CD4+/CD8+had increased from the third day,but there was no statistically significant difference(P>0.05). Conclusion:Continuous renal replacement therapy maybe improve cell immunity function in the patients with sepsis and improve the prognosis of sepsis. Also,early CRRT maybe more beneficial to the patients’ prognosis.