| Objective:previously reported that metabolic syndrome is a potential risk factor for coronary atherosclerotic heart disease, The purpose of this study is to explore the relationship between metabolic syndrome, the number of it’s components and the severity of coronary artery disease, and to further assess the predictive value of metabolic syndrome and its constituents on coronary heart disease.Materials and Methods:In this study,540cases of coronary heart disease patients which is confirmed by selective coronary angiography, According to the CDS criteria of the metabolic syndrome, all patients were divided into the MS group (164cases), and non-MS group (376cases). Meanwhile, according to the combined numbers of components of metabolic syndrome, We recorded the metabolic syndrome score of each patients, ie,0,1,2,3,4points, and then seeming them as Group0, Group1, Group2, Group3, Group4. The definition of CHD is any coronary arteries which inner diameter is more than2mm and the degree of stenosis=50%. We use the Gensini score to quantify the extent of coronary artery stenosis after coronary angiography.Results:1. Biochemical indicators, such as BMI, and FBG, TG, LDL-C, the TC UA and FIB, hypertension grading, are higher in MS patients, compared with non-MS group, while the HDL-C and LVEF are lower, the difference was statistically significant (P<0.01);2. The patients have higher Gensini score,and higher incidence of three-vessel disease and left main disease in MS patients, the difference was significant (P<0.01);3. With the increase in the numebr of combined components of MS, the coronary Gensini score is also increasing;4. The coronary Gensini scores show a positive correlation with BMI, high blood pressure classification, TG and the TC, LDL-C UA and etc,(p<0.05),and a negative correlation with gender, HDL-C,and LVEF(p<0.01); The partial correlation analysis shows that the Gensini score have a significant correlation with the number of MS components (r=0.476, p<0.01).Conclusion:1. The incidence of the metabolic syndrome is high in patients with coronary heart disease; 2. The severity of coronary lesions was higher in coronary heart disease which accompanied by metabolic syndrome, and is mainly characterized by multi-vessel disease, left main disease;3. With the increase in the number of combined components of MS, the degree of coronary lesions tended to be worse;4. MS and its various components are significantly correlated with the severity of coronary artery disease, and can be used as predictors of coronary heart disease severity. |
