1,25-dihydroxyvitamin D₃and Its Receptor And Preeclampsia Relationship

Objective To study the expression of the vitamin D receptor (VDR) in placenta in women with normal late pregnancy and preeclampsia, and to compare the difference of serum1,25-dihydroxyvitamin D3[1,25(OH)2D3] between preeclampsia maternal and normal pregnant women, as well as the possible role of vitamin D and vitamin D receptor contributing to preeclampsia。Methods A total of30preeclampsia maternal (preeclampsia group) were selected in the People’s Hospital of Gaomi between October2010and October2011. Randomly selected35cases normal late pregnancy maternal who because malposition or scar uterine underwent cesarean section as control group. The serum1,25-dihydroxyvitamin D3levels were assayed using enzyme-linked immunosorbent assay (ELISA), the expression of vitamin D receptor (VDR) protein in villi were determined by immunohistochemical experiment respectively. The correlation between the serum1,25-dihydroxyvitamin D3levels and the expression of VDR protein in villi were analyzed.Results(1) The serum levels of1,25-dihydroxyvitamin D3in preeclampsia group were significantly lower than in the control group [(37.6±8.3) pg/ml vs (54.2±10.3) pg/ml, P<0.01].(2) VDR protein were expressed in trophoblastic cells of the two pregnant groups,as shown in brown color in the cytoplasm. In preeclampsia group, pale brown were shown in the cytoplasm, whereas in the control group showed a dark brown color.(3) VDR protein in preeclampsia group of trophoblastic cells (0.23±0.11) was significantly lower than the control group (0.31±0.14), two groups were compared, the differences were statistically significant (P<0.01).(4) The serum levels of1,25-dihydroxyvitamin D3in late pregnancy were positively correlated with the expression of Vitamin D receptor (VDR) protein in villi (P<0.01).Conclusion Decreased serum levels of1,25-dihydroxyvitamin D3in late pregnancy was associated with the preeclampsia. VDR protein in preeclampsia pregnant women’s placenta organization lower expression is down, suggesting that it may be involved in the incidence of preeclampsia. Lower expression of vitamin D receptor protein in villi were positively correlated with decreased serum levels of1,25-dihydroxyvitamin D3in late pregnancy. Maybe one of the reasons of preeclampsia.